<i>Garcinia mangostana</i> peel extracts exhibit hepatoprotective activity against thioacetamide-induced liver cirrhosis in rats

Abood, Walaa Najm, Bradosty, Sarwan W, Shaikh, Faiyaz Khudaboddin, Salehen, Nur'Ain, Farghadani, Reyhaneh, Agha, Nabaz Fisal Shakir, Al-Medhtiy, Morteta H, Kamil, Treska Dhia Aldeen, Agha, Ali Salim and Abdulla, Mahmood Ameen (2020) <i>Garcinia mangostana</i> peel extracts exhibit hepatoprotective activity against thioacetamide-induced liver cirrhosis in rats. JOURNAL OF FUNCTIONAL FOODS, 74. p. 104200.

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Official URL: http://dx.doi.org/10.1016/j.jff.2020.104200

Abstract

The study in vivo evaluated the influence of ethanolic extract of G. mangostana peel on the histology, immunohistochemistry, and biochemistry of thioacetamide (TAA) induced liver cirrhosis in Sprague Drawly (SD) rats. The rats were distinctly administered with two doses of G. mangostana (250 mg/kg and 500 mg/kg) with TAA showed a significant reduction in liver index and hepatocyte proliferation with much lesser cell damage. These groups were significantly down-regulated the PCNA, α-SMA, and TGF-β1. The liver homogenate exhibited increased antioxidant enzymes (SOD and CAT) activities accompanied with decline in malondialdehyde (MDA) level. The serum level of bilirubin, total protein, albumin and liver enzymes (ALP, ALT, and AST) were restored to normal and were comparable to that normal control and silymarin with TAA treated groups. Thus normal microanatomy of hepatocytes, suppression of PCNA, α-SMA, TGF-β, improved antioxidant enzymes, reduced MDA with restoration of liver biomarkers demonstrates hepatoprotective influence of G. mangostana.

Item Type:	Article
Uncontrolled Keywords:	Traditional therapy, Garcinia mangostana, Thioacetamide, Liver cirrhosis, Hepatoprotective effect
Divisions:	Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Systems, Molecular and Integrative Biology
Depositing User:	Symplectic Admin
Date Deposited:	12 Jul 2021 09:46
Last Modified:	14 Oct 2023 15:34
DOI:	10.1016/j.jff.2020.104200
Open Access URL:	https://doi.org/10.1016/j.jff.2020.104200
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3129719