A high-stringency blueprint of the human proteome

Adhikari, Subash, Nice, Edouard C, Deutsch, Eric W, Lane, Lydie, Omenn, Gilbert S, Pennington, Stephen R, Paik, Young-Ki, Overall, Christopher M, Corrales, Fernando J, Cristea, Ileana M
et al (show 36 more authors) (2020) A high-stringency blueprint of the human proteome. NATURE COMMUNICATIONS, 11 (1). 5301-.

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The Human Proteome Organization (HUPO) launched the Human Proteome Project (HPP) in 2010, creating an international framework for global collaboration, data sharing, quality assurance and enhancing accurate annotation of the genome-encoded proteome. During the subsequent decade, the HPP established collaborations, developed guidelines and metrics, and undertook reanalysis of previously deposited community data, continuously increasing the coverage of the human proteome. On the occasion of the HPP's tenth anniversary, we here report a 90.4% complete high-stringency human proteome blueprint. This knowledge is essential for discerning molecular processes in health and disease, as we demonstrate by highlighting potential roles the human proteome plays in our understanding, diagnosis and treatment of cancers, cardiovascular and infectious diseases.

Item Type: Article
Uncontrolled Keywords: Humans, Disease, Proteome, Proteomics, Human Genome Project
Divisions: Faculty of Health and Life Sciences
Faculty of Health and Life Sciences > Institute of Systems, Molecular and Integrative Biology
Depositing User: Symplectic Admin
Date Deposited: 12 Jul 2021 09:45
Last Modified: 18 Jan 2023 21:36
DOI: 10.1038/s41467-020-19045-9
Open Access URL: http://doi.org/10.1038/s41467-020-19045-9
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3129729