Borges da Silva, Tamiris 
ORCID: 0000-0002-4563-0810
(2021)
Investigation of the immunomodulatory effects of MSC-derived extracellular vesicles on human monocyte-derived macrophages.
PhD thesis, University of Liverpool.
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Abstract
Acute kidney injury (AKI) is a common medical condition characterised by an abrupt decrease in kidney function. AKI can lead to chronic kidney disease (CKD), which has a global prevalence of approximately 10% and is linked to high morbidity and mortality. Despite the high prevalence of kidney injury, the pathophysiological mechanisms that elicit either tissue scarring or function recovery are poorly understood. Due to this lack of understanding, there is a shortage of options for effective treatments and depending on the severity of the disease the only available resources are dialysis and kidney transplantation. Hence, it is of utmost importance that new strategies are developed for the treatment of kidney injury. Macrophage polarisation has a crucial role in the context of kidney injury, as there is evidence that a shift in macrophage phenotype aids in tissue repair and function recovery. The means by which this shift takes place is still not completely elucidated, but mesenchymal stromal cells (MSCs) appear to display immunomodulatory properties that would prime macrophages towards an anti-inflammatory phenotype. MSCs have been also investigated as a means for treatment of renal diseases and recently there ... (continues)
| Item Type: | Thesis (PhD) |
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| Divisions: | Faculty of Health and Life Sciences > Institute of Systems, Molecular and Integrative Biology |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 04 Feb 2022 15:31 |
| Last Modified: | 02 Nov 2024 14:33 |
| DOI: | 10.17638/03130292 |
| Supervisors: |
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| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3130292 |
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