A microwave-triggered opening of the multifunctional polyelectrolyte capsules with nanodiamonds in the shell composition

Borodina, Tatiana, Yurina, Daria, Sokovikov, Andrey, Karimov, Denis, Bukreeva, Tatiana, Khaydukov, Evgeny and Shchukin, Dmitry ORCID: 0000-0002-2936-804X
(2021) A microwave-triggered opening of the multifunctional polyelectrolyte capsules with nanodiamonds in the shell composition. POLYMER, 212. p. 123299.

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Microcapsules are ideal cargo platform for variety of applications such as drug delivery, sensing and imaging due to the combination of a simplicity fabrication and flexibility in the design. We developed remotely collapsing polymer capsules to response to external microwave treatment. The multilayer structure of the capsules was designed to create a polyfunctional system intercalating with nanodiamonds (NDs) and upconversion nanoparticles (UCNPs) into the polyelectrolyte shell. NDs empower local overheating to the microcapsules, while UCNPs provide opportunity to luminescent thermal sensing. UCNPs consist of inorganic crystalline host matrix - hexagonal β-phase NaYF4, doped with pairs of trivalent lanthanide ions, which play role of sensitizer (Yb3+) and activator (Er3+). The microwave triggering followed by the capsule heating results in the controlled destruction of the polyelectrolyte shell with subsequent cargo release. UCNPs luminescence was utilized to determine the local temperature of the capsule shell at nanoscale under GHz ultrasonic treatment. Our novel approach provides on demand microcapsule system destruction, which can be used in the development of nanotheranostic platform for the unification of diagnosis and treatment of various diseases.

Item Type: Article
Uncontrolled Keywords: Nanodiamonds, Multilayer polyelectrolyte capsules, Upconversion nanoparticles, External triggering, Microwave treatment, Multifunctional system
Divisions: Faculty of Science and Engineering > School of Physical Sciences
Depositing User: Symplectic Admin
Date Deposited: 23 Jul 2021 07:10
Last Modified: 18 Jan 2023 21:35
DOI: 10.1016/j.polymer.2020.123299
Open Access URL: https://reader.elsevier.com/reader/sd/pii/S0032386...
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URI: https://livrepository.liverpool.ac.uk/id/eprint/3130976