Hobson, James 
ORCID: 0000-0003-2551-1774, Savage, Alison ORCID: 0000-0002-5312-9946, Dwyer, Andrew, Unsworth, Catherine, Arshad, Usman ORCID: 0000-0003-1586-1885, Pertinez, Henry, box, helen, Tatham, Lee ORCID: 0000-0001-9448-8876, Rajoli, Rajith KR ORCID: 0000-0002-6015-5712, Neary, Megan et al (show 8 more authors)
(2021)
Scalable nanoprecipitation of niclosamide and in vivo demonstration of long-acting delivery after intramuscular injection.
Abstract
<jats:p><p>The spread of SARS-CoV-2 across the world requires the formation of a range of interventions that include immunomodulatory or antiviral therapeutics and repurposing of existing drug compounds is an important strategy to rapidly identify possible options. Niclosamide is a cheap and generic drug compound with a proven <i>in vitro</i> ability to inhibit viral replication of SARS-CoV-2; this drug also has known poor oral bioavailability due to very low water solubility. Here, we demonstrate the nanoparticle formulation of niclosamide using a new, cheap and scalable process to enable long-acting injectable administration and show extended circulating drug exposure <i>in vivo</i> over 28 days using a rodent model after depot injection.</p></jats:p>
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Lung, Pneumonia, Emerging Infectious Diseases, Prevention, Biodefense, Vaccine Related, 5.1 Pharmaceuticals, 5 Development of treatments and therapeutic interventions, Infection, 3 Good Health and Well Being |
| Divisions: | Faculty of Science and Engineering > School of Physical Sciences |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 09 Aug 2021 10:46 |
| Last Modified: | 11 Apr 2024 16:38 |
| DOI: | 10.26434/chemrxiv.13587035 |
| Open Access URL: | https://pubs.rsc.org/en/content/articlelanding/202... |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3132903 |
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