Association of Epilepsy Surgery With Changes in Imaging-Defined Brain Age

de Bezenac, Christophe E, Adan, Guleed ORCID: 0000-0001-7340-4207, Weber, Bernd and Keller, Simon S ORCID: 0000-0001-5247-9795
(2021) Association of Epilepsy Surgery With Changes in Imaging-Defined Brain Age. NEUROLOGY, 97 (6). E554-E563.

Access the full-text of this item by clicking on the Open Access link.


<h4>Objective</h4>To determine whether surgery in patients with mesial temporal lobe epilepsy (mTLE) is associated with reduced brain-predicted age as a neural marker overall brain health, we compared brain-predicted and chronologic age difference (brain age gap estimation [BrainAGE]) in patients before and after surgery with healthy controls.<h4>Methods</h4>We acquired 3D T1-weighted MRI scans for 48 patients with mTLE before and after temporal lobe surgery to estimate brain age using a gaussian processes regression model. We examined BrainAGE before and after surgery controlling for brain volume change, comparing patients to 37 age- and sex-matched controls.<h4>Results</h4>Preoperatively, patients showed an increased BrainAGE of more than 7 years compared to controls. However, surgery was associated with a mean BrainAGE reduction of 5 years irrespective of whether or not surgery resulted in complete seizure freedom. We observed a lateralization effect as patients with left mTLE had BrainAGE values that more closely resembled control group values following surgery.<h4>Conclusions</h4>Our findings suggest that while morphologic brain alterations linked to accelerated aging have been observed in mTLE, surgery may be associated with changes that reverse such alterations in some patients. This work highlights the advantages of resective surgery on overall brain health in patients with refractory focal epilepsy.

Item Type: Article
Uncontrolled Keywords: Humans, Epilepsy, Temporal Lobe, Aging, Premature, Magnetic Resonance Imaging, Follow-Up Studies, Adolescent, Adult, Aged, Middle Aged, Female, Male, Young Adult, Drug Resistant Epilepsy, Outcome Assessment, Health Care
Divisions: Faculty of Health and Life Sciences
Faculty of Health and Life Sciences > Institute of Systems, Molecular and Integrative Biology
Depositing User: Symplectic Admin
Date Deposited: 12 Aug 2021 07:55
Last Modified: 18 Jan 2023 21:33
DOI: 10.1212/WNL.0000000000012289
Open Access URL:
Related URLs: