Wang, Weina, Wu, Xintong, Su, Xiaorui, Sun, Huaiqiang, Tan, Qiaoyue, Zhang, Simin, Lu, Lu, Gao, Hui, Liu, Wenyu, Yang, Xibiao et al (show 4 more authors)
(2021)
Metabolic alterations of the dorsolateral prefrontal cortex in sleep-related hypermotor epilepsy: A proton magnetic resonance spectroscopy study.
JOURNAL OF NEUROSCIENCE RESEARCH, 99 (10).
pp. 2657-2668.
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Abstract
Sleep-related hypermotor epilepsy (SHE) is a focal epilepsy whose neurobiological underpinnings remain poorly understood. The present study aimed to identify possible neurochemical alterations in the dorsolateral prefrontal cortex (DLPFC) in participants with SHE using proton magnetic resonance spectroscopy (<sup>1</sup> H MRS). Thirty-nine participants with SHE (mean age, 30.7 years ± 11.3 [standard deviation], 24 men) and 59 controls (mean age, 29.4 years ± 10.4, 29 men) were consecutively and prospectively recruited and underwent brain magnetic resonance imaging and <sup>1</sup> H MRS in the bilateral DLPFCs. Brain concentrations of metabolites, including N-acetyl aspartate (NAA), myo-inositol (mI), choline, creatine, the sum of glutamate and glutamine, glutathione (GSH) and γ-aminobutyric acid, were estimated with LCModel and corrected for the partial volume effect of cerebrospinal fluid using tissue segmentation. ANCOVA analyses revealed lower concentration of NAA in the left DLPFC in participants with SHE compared with controls. A significant difference of NAA concentration between DLPFC in the two hemispheres (left > right) was observed only in the control group. We further confirmed a higher GSH concentration in men than in women in SHE participants, which probably indicates that men are more susceptible to this disease. The mI concentration in the right DLPFC was negatively correlated with epilepsy duration. This study demonstrates that DLPFC is an important brain region involved in the pathophysiology of SHE, in which both neurons and astrocytes appear impaired, and the elevated GSH level may suggest an abnormality related to oxidative stress.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | dorsolateral prefrontal cortex, epilepsy, GABA, magnetic resonance spectroscopy, sleep-related hypermotor epilepsy |
| Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 20 Aug 2021 10:15 |
| Last Modified: | 18 Jan 2023 21:33 |
| DOI: | 10.1002/jnr.24866 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3134050 |
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