Minimally Invasive Surgery For Neuroblastic Tumors : A SIOPEN Multicenter Study: Proposal For Guidelines.

Gabra, Hany, Irtan, Sabine, Cross, Kate, Lobos, Pablo, Froeba-Pohl, Alexandra, Pio, Luca, Virgone, Calogero, Guillén Burrieza, Gabriela, Gómez Chacón, Javier, Riccipetitoni, Giovanna
et al (show 14 more authors) (2021) Minimally Invasive Surgery For Neuroblastic Tumors : A SIOPEN Multicenter Study: Proposal For Guidelines. European Journal of Surgical Oncology, 48 (1). pp. 283-291.

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<h4>Introduction</h4>Surgery plays a key role in the management of Neuroblastic tumours (NB), where the standard approach is open surgery, while minimally invasive surgery (MIS) may be considered an option in selected cases. The indication(s) and morbidity of MIS remain undetermined due to small number of reported studies. The aim of this study was to critically address the contemporary indications, morbidity and overall survival (OS) and propose guidelines exploring the utility of MIS for NB.<h4>Materials & methods</h4>A SIOPEN study where data of patients with NB who underwent MIS between 2005 and 2018, including demographics, tumour features, imaging, complications, follow up and survival, were extracted and then analysed.<h4>Results</h4>A total of 222 patients from 16 centres were identified. The majority were adrenal gland origin (54%) compared to abdominal non-adrenal and pelvic (16%) and thoracic (30%). Complete and near complete macroscopic resection (>95%) was achieved in 95%, with 10% of cases having conversion to open surgery. Complications were reported in 10% within 30 days of surgery. The presence of IDRF (30%) and/or tumour volume >75 ml were risk factors for conversion and complications in multivariate analysis. Overall mortality was 8.5%.<h4>Conclusions</h4>MIS for NB showed that it is a secure approach allowing more than 95% resection. The presence of IDRFs was not an absolute contraindication for MIS. Conversion to open surgery and overall complication rates were low, however they become significant if tumour volume >75 mL. Based on these data, we propose new MIS guidelines for neuroblastic tumours.

Item Type: Article
Uncontrolled Keywords: Neuroblastoma, Minimally invasive surgery, IDRF, Clinical outcomes
Divisions: Faculty of Health and Life Sciences
Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences
Depositing User: Symplectic Admin
Date Deposited: 24 Aug 2021 07:47
Last Modified: 18 Jan 2023 21:32
DOI: 10.1016/j.ejso.2021.08.013
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