Risk factors for post-COVID-19 condition in previously hospitalised children using the ISARIC Global follow-up protocol: a prospective cohort study.



Osmanov, Ismail M, Spiridonova, Ekaterina, Bobkova, Polina, Gamirova, Aysylu, Shikhaleva, Anastasia, Andreeva, Margarita, Blyuss, Oleg ORCID: 0000-0002-0194-6389, El-Taravi, Yasmin ORCID: 0000-0002-4218-4456, DunnGalvin, Audrey, Comberiati, Pasquale ORCID: 0000-0001-5209-9733
et al (show 29 more authors) (2022) Risk factors for post-COVID-19 condition in previously hospitalised children using the ISARIC Global follow-up protocol: a prospective cohort study. The European respiratory journal, 59 (2). 2101341 - ?.

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Abstract

The long-term sequelae of coronavirus disease 2019 (COVID-19) in children remain poorly characterised. This study aimed to assess long-term outcomes in children previously hospitalised with COVID-19 and associated risk factors. This is a prospective cohort study of children (≤18 years old) admitted to hospital with confirmed COVID-19. Children admitted between 2 April 2020 and 26 August 2020 were included. Telephone interviews used the International Severe Acute Respiratory and Emerging Infection Consortium (ISARIC) COVID-19 Health and Wellbeing Follow-up Survey for Children. Persistent symptoms (>5 months) were further categorised by system(s) involved. 518 out of 853 (61%) eligible children were available for the follow-up assessment and included in the study. Median (interquartile range (IQR)) age was 10.4 (3-15.2) years and 270 (52.1%) were girls. Median (IQR) follow-up since hospital discharge was 256 (223-271) days. At the time of the follow-up interview 126 (24.3%) participants reported persistent symptoms, among which fatigue (53, 10.7%), sleep disturbance (36, 6.9%) and sensory problems (29, 5.6%) were the most common. Multiple symptoms were experienced by 44 (8.4%) participants. Risk factors for persistent symptoms were: older age "6-11 years" (OR 2.74, 95% CI 1.37-5.75) and "12-18 years" (OR 2.68, 95% CI 1.41-5.4), and a history of allergic diseases (OR 1.67, 95% CI 1.04-2.67). A quarter of children experienced persistent symptoms months after hospitalisation with acute COVID-19 infection, with almost one in 10 experiencing multisystem involvement. Older age and allergic diseases were associated with higher risk of persistent symptoms at follow-up.

Item Type: Article
Uncontrolled Keywords: and the Sechenov StopCOVID Research Team, Humans, Risk Factors, Follow-Up Studies, Prospective Studies, Adolescent, Aged, Child, Child, Hospitalized, Female, COVID-19, SARS-CoV-2
Divisions: Faculty of Health and Life Sciences
Faculty of Health and Life Sciences > Institute of Infection, Veterinary and Ecological Sciences
Depositing User: Symplectic Admin
Date Deposited: 30 Sep 2021 08:11
Last Modified: 14 May 2022 03:10
DOI: 10.1183/13993003.01341-2021
Open Access URL: https://erj.ersjournals.com/content/early/2021/06/...
URI: https://livrepository.liverpool.ac.uk/id/eprint/3138699