Risk factors for long covid in previously hospitalised children using the ISARIC Global follow-up protocol: A prospective cohort study.



Osmanov, Ismail M, Spiridonova, Ekaterina, Bobkova, Polina, Gamirova, Aysylu, Shikhaleva, Anastasia, Andreeva, Margarita, Blyuss, Oleg, El-Taravi, Yasmin, DunnGalvin, Audrey, Comberiati, Pasquale ORCID: 0000-0001-5209-9733
et al (show 29 more authors) (2021) Risk factors for long covid in previously hospitalised children using the ISARIC Global follow-up protocol: A prospective cohort study. The European respiratory journal.

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Abstract

<h4>Background</h4>The long-term sequelae of coronavirus disease 2019 (Covid-19) in children remain poorly characterised. This study aimed to assess long-term outcomes in children previously hospitalised with Covid-19 and associated risk factors.<h4>Methods</h4>This is a prospective cohort study of children (≤18 years old) admitted with confirmed Covid-19. Children admitted to the hospital between April 2, 2020 and August 26, 2020, were included. Telephone interview using the International Severe Acute Respiratory and emerging Infection Consortium (ISARIC) Covid-19 Health and Wellbeing paediatric follow-up survey. Persistent symptoms (>5 months) were further categorised by system(s) involved.<h4>Findings</h4>518 of 853 (61%) of eligible children were available for the follow-up assessment and included in the study. Median age was 10.4 years (IQR, 3-15.2) and 270 (52.1%) were girls; median follow-up since hospital discharge was 256 (223-271) days. At the time of the follow-up interview 126 (24.3%) participants reported persistent symptoms among which fatigue (53, 10.7%), sleep disturbance (36, 6.9%,) and sensory problems (29, 5.6%) were the most common. Multiple symptoms were experienced by 44 (8.4%) participants. Risk factors for persistent symptoms were: older age "6-11 years" (odds ratio 2.74 (95% confidence interval 1.37 to 5.75) and "12-18 years" (2.68, 1.41 to 5.4); and a history of allergic diseases (1.67, 1.04 to 2.67).<h4>Interpretation</h4>A quarter of children experienced persistent symptoms months after hospitalization with acute covid-19 infection, with almost one in ten experiencing multi-system involvement. Older age and allergic diseases were associated with higher risk of persistent symptoms at follow-up.

Item Type: Article
Uncontrolled Keywords: Sechenov StopCOVID Research Team
Divisions: Faculty of Health and Life Sciences
Faculty of Health and Life Sciences > Institute of Infection, Veterinary and Ecological Sciences
Depositing User: Symplectic Admin
Date Deposited: 30 Sep 2021 08:11
Last Modified: 08 Jan 2022 04:10
DOI: 10.1183/13993003.01341-2021
Open Access URL: https://erj.ersjournals.com/content/early/2021/06/...
URI: https://livrepository.liverpool.ac.uk/id/eprint/3138699