Pauley, Ellen 
ORCID: 0000-0001-6994-9722, Drake, Thomas, Griffith, David ORCID: 0000-0001-9500-241X, Lone, Nazir ORCID: 0000-0003-2707-2779, Harrison, Ewen ORCID: 0000-0002-5018-3066, Baillie, Kenneth ORCID: 0000-0001-5258-793X, Scott, Janet ORCID: 0000-0001-8030-5223, Walsh, Timothy ORCID: 0000-0002-3590-8540, Semple, Malcolm ORCID: 0000-0001-9700-0418 and Docherty, Annemarie
(2021)
Recovery from Covid-19 critical illness: a secondary analysis of the ISARIC4C CCP-UK cohort study and the RECOVER trial.
[Preprint]
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Abstract
<h4>Background</h4> We aimed to compare the prevalence and severity of fatigue in survivors of Covid-19 versus non-Covid-19 critical illness, and to explore potential associations between baseline characteristics and worse recovery. <h4>Methods</h4> We conducted a secondary analysis of two prospectively collected datasets. The population included was 92 patients who received invasive mechanical ventilation (IMV) with Covid-19, and 240 patients who received IMV with non-Covid-19 illness before the pandemic. Follow-up data was collected post-hospital discharge using self-reported questionnaires. The main outcome measures were self-reported fatigue severity and the prevalence of severe fatigue (severity >7/10) 3 and 12-months post-hospital discharge. <h4>Results</h4> Covid-19 IMV-patients were significantly younger with less prior comorbidity, and more males, than pre-pandemic IMV-patients. At 3-months, the prevalence (38.9% [7/18] vs. 27.1% [51/188]) and severity (median 5.5/10 vs. 5.0/10) of fatigue was similar between the Covid-19 and pre-pandemic populations respectively. At 6-months, the prevalence (10.3% [3/29] vs. 32.5% [54/166]) and severity (median 2.0/10 vs. 5.7/10) of fatigue was less in the Covid-19 cohort. In the Covid-19 population, women under 50 experienced more severe fatigue, breathlessness, and worse overall health state compared to other Covid-19 IMV-patients. There were no significant sex differences in long-term outcomes in the pre-pandemic population. In the total sample of IMV-patients included (i.e. all Covid-19 and pre-pandemic patients), having Covid-19 was significantly associated with less severe fatigue (severity <7/10) after adjusting for age, sex, and prior comorbidity (adjusted OR 0.35 (95%CI 0.15-0.76, p=0.01). <h4>Conclusion</h4> Fatigue may be less severe after Covid-19 than after other critical illness.
| Item Type: | Preprint |
|---|---|
| Uncontrolled Keywords: | Rehabilitation, Clinical Research, 7.1 Individual care needs, 2 Aetiology, 7 Management of diseases and conditions, 2.4 Surveillance and distribution, 3 Good Health and Well Being |
| Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Infection, Veterinary and Ecological Sciences |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 30 Sep 2021 08:09 |
| Last Modified: | 14 Mar 2024 20:33 |
| DOI: | 10.1101/2021.06.15.21258879 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3138701 |
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