Fatal COVID-19 outcomes are associated with an antibody response targeting epitopes shared with endemic coronaviruses



McNaughton, Anna, Paton, Robert, Edmans, Matthew, Youngs, Jonathan, Wellens, Judith, Phalora, Prabhjeet, Fyfe, Alex, Belij-Rammerstorfer, Sandra, Bolton, Jai, Ball, Jonathan
et al (show 47 more authors) (2021) Fatal COVID-19 outcomes are associated with an antibody response targeting epitopes shared with endemic coronaviruses.

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Abstract

<h4>Summary</h4> It is unclear whether prior endemic coronavirus infections affect COVID-19 severity. Here, we show that in cases of fatal COVID-19, antibody responses to the SARS-COV-2 spike are directed against epitopes shared with endemic beta-coronaviruses in the S2 subunit of the SARS-CoV-2 spike protein. This immune response is associated with the compromised production of a de novo SARS-CoV-2 spike response among individuals with fatal COVID-19 outcomes.

Item Type: Article
Uncontrolled Keywords: OPTIC consortium, SNBTS consortium, ISARIC4C Investigators
Divisions: Faculty of Health and Life Sciences
Faculty of Health and Life Sciences > Institute of Infection, Veterinary and Ecological Sciences
Depositing User: Symplectic Admin
Date Deposited: 30 Sep 2021 08:00
Last Modified: 16 Dec 2021 19:11
DOI: 10.1101/2021.05.04.21256571
Open Access URL: https://www.medrxiv.org/content/10.1101/2021.05.04...
URI: https://livrepository.liverpool.ac.uk/id/eprint/3138711