Fatal COVID-19 outcomes are associated with an antibody response targeting epitopes shared with endemic coronaviruses

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McNaughton, Anna ORCID: 0000-0002-7436-8727, Paton, Robert, Edmans, Matthew, Youngs, Jonathan, Wellens, Judith, Phalora, Prabhjeet, Fyfe, Alex, Belij-Rammerstorfer, Sandra, Bolton, Jai, Ball, Jonathan ORCID: 0000-0002-5553-7329 et al (show 47 more authors) , Carnell, George ORCID: 0000-0001-8875-0989, Dejnirattisai, Wanwisa, Dold, Christina, Eyre, David ORCID: 0000-0001-5095-6367, Hopkins, Philip ORCID: 0000-0002-3713-8391, Howarth, Alison, Kooblall, Kreepa, Klim, Hannah, Leaver, Susannah, Lee, Lian, López-Camacho, César, Lumley, Sheila, Macallan, Derek, Mentzer, Alexander ORCID: 0000-0002-4502-2209, Provine, Nicholas, Ratcliff, Jeremy, Slon-Compos, Jose, Skelly, Donal, Stolle, Lucas, Supasa, Piyada, Temperton, Nigel ORCID: 0000-0002-7978-3815, Walker, Chris, Wang, Beibei, Wyncoll, Duncan, OPTIC consortium, SNBTS consortium, Simmonds, Peter, Lambe, Teresa ORCID: 0000-0001-9700-0418, Baillie, Kenneth, Semple, Malcolm ORCID: 0000-0001-9700-0418, Openshaw, Peter IM, ISARIC4C Investigators, Obolski, Uri, Turner, Marc, Carroll, Miles, Mongkolsapaya, Juthathip, Screaton, Gavin ORCID: 0000-0002-0860-0831, Kennedy, Stephen ORCID: 0000-0001-5665-6293, Jarvis, Lisa, Barnes, Eleanor, Dunachie, Susanna, Lourenço, José ORCID: 0000-0003-4307-9161, Matthews, Philippa ORCID: 0000-0002-4036-4269, Bicanic, Tihana ORCID: 0000-0001-9248-9365, Klenerman, Paul, Gupta, Sunetra and Thompson, Craig (2021) Fatal COVID-19 outcomes are associated with an antibody response targeting epitopes shared with endemic coronaviruses [Preprint]

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Abstract

<h4>Summary</h4> It is unclear whether prior endemic coronavirus infections affect COVID-19 severity. Here, we show that in cases of fatal COVID-19, antibody responses to the SARS-COV-2 spike are directed against epitopes shared with endemic beta-coronaviruses in the S2 subunit of the SARS-CoV-2 spike protein. This immune response is associated with the compromised production of a de novo SARS-CoV-2 spike response among individuals with fatal COVID-19 outcomes.

Item Type:	Preprint
Additional Information:	Source info: CP-COMMUNITY-D-21-00179
Uncontrolled Keywords:	OPTIC consortium, SNBTS consortium, ISARIC4C Investigators
Divisions:	Faculty of Health & Life Sciences Faculty of Health & Life Sciences > Inst. Infection, Vet & Ecological Sciences
Depositing User:	Symplectic Admin
Date Deposited:	30 Sep 2021 08:00
Last Modified:	29 May 2026 06:51
DOI:	10.1101/2021.05.04.21256571
Open Access URL:	https://www.medrxiv.org/content/10.1101/2021.05.04...
Related Websites:	Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3138711
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