Flood, Jessica, Shingleton, Joseph, Bennett, Emma, Walker, Brodie, Amin-Chowdhury, Zahin, Oligbu, Godwin, Avis, Jacob, Lynn, Richard M, Davis, Peter, Bharucha, Tara et al (show 13 more authors)
(2021)
Paediatric multisystem inflammatory syndrome temporally associated with SARS-CoV-2 (PIMS-TS): Prospective, national surveillance, United Kingdom and Ireland, 2020
LANCET REGIONAL HEALTH-EUROPE, 3.
100075-.
ISSN 2666-7762, 2666-7762
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Text
Paediatric multisystem inflammatory syndrome temporally associated with SARS-CoV-2 (PIMS-TS) Prospective, national surveilla.pdf - Published version Download (1MB) | Preview |
Abstract
Background: Paediatric Multisystem Inflammatory Syndrome temporally associated with SARS-CoV-2 (PIMS-TS), first identified in April 2020, shares features of both Kawasaki disease (KD) and toxic shock syndrome (TSS). The surveillance describes the epidemiology and clinical characteristics of PIMS-TS in the United Kingdom and Ireland. Methods: Public Health England initiated prospective national surveillance of PIMS-TS through the British Paediatric Surveillance Unit. Paediatricians were contacted monthly to report PIMS-TS, KD and TSS cases electronically and complete a detailed clinical questionnaire. Cases with symptom onset between 01 March and 15 June 2020 were included. Findings: There were 216 cases with features of PIMS-TS alone, 13 with features of both PIMS-TS and KD, 28 with features of PIMS-TS and TSS and 11 with features of PIMS-TS, KD and TSS, with differences in age, ethnicity, clinical presentation and disease severity between the phenotypic groups. There was a strong geographical and temporal association between SARS-CoV-2 infection rates and PIMS-TS cases. Of those tested, 14.8% (39/264) children had a positive SARS-CoV-2 RT-PCR, and 63.6% (75/118) were positive for SARS-CoV-2 antibodies. In total 44·0% (118/268) required intensive care, which was more common in cases with a TSS phenotype. Three of five children with cardiac arrest had TSS phenotype. Three children (1·1%) died. Interpretation: The strong association between SARS-CoV-2 infection and PIMS-TS emphasises the importance of maintaining low community infection rates to reduce the risk of this rare but severe complication in children and adolescents. Close follow-up will be important to monitor long-term complications in children with PIMS-TS. Funding: PHE.
| Item Type: | Article |
|---|---|
| Additional Information: | Source info: THELANCETID-D-21-00212 |
| Uncontrolled Keywords: | 3207 Medical Microbiology, 32 Biomedical and Clinical Sciences, 42 Health Sciences, Health Disparities and Racial or Ethnic Minority Health Research, Cardiovascular, Coronaviruses, Clinical Research, Pediatric Research Initiative, Heart Disease, Health Disparities, Infectious Diseases, Rare Diseases, Autoimmune Disease, Coronaviruses Disparities and At-Risk Populations, Emerging Infectious Diseases, 2.4 Surveillance and distribution, 3 Good Health and Well Being |
| Divisions: | Faculty of Health & Life Sciences Faculty of Health & Life Sciences > Inst. Infection, Vet & Ecological Sciences |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 30 Sep 2021 07:59 |
| Last Modified: | 16 Jun 2026 10:18 |
| DOI: | 10.1016/j.lanepe.2021.100075 |
| Related Websites: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3138713 |
| Disclaimer: | The University of Liverpool is not responsible for content contained on other websites from links within repository metadata. Please contact us if you notice anything that appears incorrect or inappropriate. |
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