Paediatric multisystem inflammatory syndrome temporally associated with SARS-CoV-2 (PIMS-TS): Prospective, national surveillance, United Kingdom and Ireland, 2020.



Flood, Jessica, Shingleton, Joseph, Bennett, Emma ORCID: 0000-0001-7188-4315, Walker, Brodie, Amin-Chowdhury, Zahin, Oligbu, Godwin, Avis, Jacob, Lynn, Richard M ORCID: 0000-0001-8474-7459, Davis, Peter, Bharucha, Tara
et al (show 13 more authors) (2021) Paediatric multisystem inflammatory syndrome temporally associated with SARS-CoV-2 (PIMS-TS): Prospective, national surveillance, United Kingdom and Ireland, 2020. The Lancet regional health. Europe, 3. 100075 - ?.

[img] Text
Paediatric multisystem inflammatory syndrome temporally associated with SARS-CoV-2 (PIMS-TS) Prospective, national surveilla.pdf - OA Published Version

Download (1MB) | Preview

Abstract

<h4>Background</h4>Paediatric Multisystem Inflammatory Syndrome temporally associated with SARS-CoV-2 (PIMS-TS), first identified in April 2020, shares features of both Kawasaki disease (KD) and toxic shock syndrome (TSS). The surveillance describes the epidemiology and clinical characteristics of PIMS-TS in the United Kingdom and Ireland.<h4>Methods</h4>Public Health England initiated prospective national surveillance of PIMS-TS through the British Paediatric Surveillance Unit. Paediatricians were contacted monthly to report PIMS-TS, KD and TSS cases electronically and complete a detailed clinical questionnaire. Cases with symptom onset between 01 March and 15 June 2020 were included.<h4>Findings</h4>There were 216 cases with features of PIMS-TS alone, 13 with features of both PIMS-TS and KD, 28 with features of PIMS-TS and TSS and 11 with features of PIMS-TS, KD and TSS, with differences in age, ethnicity, clinical presentation and disease severity between the phenotypic groups. There was a strong geographical and temporal association between SARS-CoV-2 infection rates and PIMS-TS cases. Of those tested, 14.8% (39/264) children had a positive SARS-CoV-2 RT-PCR, and 63.6% (75/118) were positive for SARS-CoV-2 antibodies. In total 44·0% (118/268) required intensive care, which was more common in cases with a TSS phenotype. Three of five children with cardiac arrest had TSS phenotype. Three children (1·1%) died.<h4>Interpretation</h4>The strong association between SARS-CoV-2 infection and PIMS-TS emphasises the importance of maintaining low community infection rates to reduce the risk of this rare but severe complication in children and adolescents. Close follow-up will be important to monitor long-term complications in children with PIMS-TS.<h4>Funding</h4>PHE.

Item Type: Article
Divisions: Faculty of Health and Life Sciences
Faculty of Health and Life Sciences > Institute of Infection, Veterinary and Ecological Sciences
Depositing User: Symplectic Admin
Date Deposited: 30 Sep 2021 07:59
Last Modified: 09 Sep 2022 10:49
DOI: 10.1016/j.lanepe.2021.100075
URI: https://livrepository.liverpool.ac.uk/id/eprint/3138713