A novel nairovirus associated with acute febrile illness in Hokkaido, Japan

Kodama, Fumihiro, Yamaguchi, Hiroki, Park, Eunsil, Tatemoto, Kango, Sashika, Mariko, Nakao, Ryo, Terauchi, Yurino, Mizuma, Keita, Orba, Yasuko, Kariwa, Hiroaki
et al (show 20 more authors) (2021) A novel nairovirus associated with acute febrile illness in Hokkaido, Japan. NATURE COMMUNICATIONS, 12 (1). 5539-.

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The increasing burden of tick-borne orthonairovirus infections, such as Crimean-Congo hemorrhagic fever, is becoming a global concern for public health. In the present study, we identify a novel orthonairovirus, designated Yezo virus (YEZV), from two patients showing acute febrile illness with thrombocytopenia and leukopenia after tick bite in Hokkaido, Japan, in 2019 and 2020, respectively. YEZV is phylogenetically grouped with Sulina virus detected in Ixodes ricinus ticks in Romania. YEZV infection has been confirmed in seven patients from 2014-2020, four of whom were co-infected with Borrelia spp. Antibodies to YEZV are found in wild deer and raccoons, and YEZV RNAs have been detected in ticks from Hokkaido. In this work, we demonstrate that YEZV is highly likely to be the causative pathogen of febrile illness, representing the first report of an endemic infection associated with an orthonairovirus potentially transmitted by ticks in Japan.

Item Type: Article
Uncontrolled Keywords: Animals, Humans, Ixodes, Nairovirus, Virion, Fever, RNA, Viral, Antibodies, Viral, Leukocyte Count, Phylogeny, Genome, Viral, Adult, Middle Aged, Japan, Male
Divisions: Faculty of Health and Life Sciences
Faculty of Health and Life Sciences > Institute of Infection, Veterinary and Ecological Sciences
Depositing User: Symplectic Admin
Date Deposited: 07 Oct 2021 10:36
Last Modified: 18 Jan 2023 21:27
DOI: 10.1038/s41467-021-25857-0
Open Access URL: https://doi.org/10.1038/s41467-021-25857-0
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3139598