The non-coding RNA interactome in joint health and disease

Ali, Shabana A, Peffers, Mandy J ORCID: 0000-0001-6979-0440, Ormseth, Michelle J, Jurisica, Igor and Kapoor, Mohit (2021) The non-coding RNA interactome in joint health and disease Nature Reviews Rheumatology, 17 (11). pp. 692-705. ISSN 1759-4790, 1759-4804

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Abstract

Non-coding RNAs have distinct regulatory roles in the pathogenesis of joint diseases including osteoarthritis (OA) and rheumatoid arthritis (RA). As the amount of high-throughput profiling studies and mechanistic investigations of microRNAs, long non-coding RNAs and circular RNAs in joint tissues and biofluids has increased, data have emerged that suggest complex interactions among non-coding RNAs that are often overlooked as critical regulators of gene expression. Identifying these non-coding RNAs and their interactions is useful for understanding both joint health and disease. Non-coding RNAs regulate signalling pathways and biological processes that are important for normal joint development but, when dysregulated, can contribute to disease. The specific expression profiles of non-coding RNAs in various disease states support their roles as promising candidate biomarkers, mediators of pathogenic mechanisms and potential therapeutic targets. This Review synthesizes literature published in the past 2 years on the role of non-coding RNAs in OA and RA with a focus on inflammation, cell death, cell proliferation and extracellular matrix dysregulation. Research to date makes it apparent that ‘non-coding’ does not mean ‘non-essential’ and that non-coding RNAs are important parts of a complex interactome that underlies OA and RA.

Item Type:	Article
Uncontrolled Keywords:	Joints, Humans, Joint Diseases, Arthritis, Rheumatoid, Osteoarthritis, Inflammation, RNA, RNA, Untranslated, Genomics, Gene Expression Regulation, Epigenesis, Genetic, Biomarkers
Divisions:	Faculty of Health & Life Sciences Faculty of Health & Life Sciences > Inst. Life Courses & Medical Sciences
Depositing User:	Symplectic Admin
Date Deposited:	15 Oct 2021 09:24
Last Modified:	28 Feb 2026 23:38
DOI:	10.1038/s41584-021-00687-y
Related Websites:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3140486
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