Freiche, Valerie, Fages, Julien, Paulin, Mathieu Victor, Bruneau, Julie, Couronne, Lucile, German, Alexander J 
ORCID: 0000-0002-3017-7988, Penninck, Dominique and Hermine, Olivier
(2021)
Clinical, laboratory and ultrasonographic findings differentiating low-grade intestinal T-cell lymphoma from lymphoplasmacytic enteritis in cats
JOURNAL OF VETERINARY INTERNAL MEDICINE, 35 (6).
pp. 2685-2696.
ISSN 0891-6640, 1939-1676
Abstract
Background: Low-grade intestinal T-cell lymphoma (LGITL) is the most common intestinal neoplasm in cats. Differentiating LGITL from lymphoplasmacytic enteritis (LPE) is challenging because clinical signs, laboratory results, diagnostic imaging findings, histology, immunohistochemistry, and clonality features may overlap. Objectives: To evaluate possible discriminatory clinical, laboratory and ultrasonographic features to differentiate LGITL from LPE. Animals: Twenty-two cats diagnosed with LGITL and 22 cats with LPE based upon histology, immunohistochemistry, and lymphoid clonality. Methods: Prospective, cohort study. Cats presented with clinical signs consistent with LGITL or LPE were enrolled prospectively. All data contributing to the diagnostic evaluation was recorded. Results: A 3-variable model (P <.001) consisting of male sex (P =.01), duration of clinical signs (P =.01), and polyphagia (P =.03) and a 2-variable model (P <.001) including a rounded jejunal lymph node (P <.001) and ultrasonographic abdominal effusion (P =.04) were both helpful to differentiate LGITL from LPE. Conclusions and Clinical Importance: Most clinical signs and laboratory results are similar between cats diagnosed with LGITL and LPE. However, male sex, a longer duration of clinical signs and polyphagia might help clinicians distinguish LGITL from LPE. On ultrasonography, a rounded jejunal lymph node, and the presence of (albeit small volume) abdominal effusion tended to be more prevalent in cats with LGITL. However, a definitive diagnosis requires comprehensive histopathologic and phenotypic assessment.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | alimentary lymphoma, cat, chronic enteropathy, full-thickness intestinal biopsies, inflammatory bowel disease, ultrasonography |
| Divisions: | Faculty of Health & Life Sciences Faculty of Health & Life Sciences > Inst. Life Courses & Medical Sciences |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 25 Oct 2021 08:35 |
| Last Modified: | 23 May 2026 06:22 |
| DOI: | 10.1111/jvim.16272 |
| Open Access URL: | https://onlinelibrary.wiley.com/doi/epdf/10.1111/j... |
| Related Websites: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3141581 |
| Disclaimer: | The University of Liverpool is not responsible for content contained on other websites from links within repository metadata. Please contact us if you notice anything that appears incorrect or inappropriate. |
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