Till, Kathleen 
ORCID: 0000-0002-3172-5771, Alnassfan, tahera, Cox-Pridmore, Megan and Taktak, Azzam
(2021)
Mantle Cell Lymphoma Treatment Options for Elderly/Unfit Patients: A Systematic Review.
ejHaem, 3 (1).
pp. 276-290.
ISSN 2688-6146, 2688-6146
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Text
MCL review.pdf - Published version Download (888kB) | Preview |
Abstract
Mantle cell lymphoma (MCL) is a rare B-cell non-Hodgkin lymphoma (NHL) that is aggressive and incurable with existing therapies, presenting a significant unmet clinical need. MCL occurs mainly in elderly patients with comorbidities; thus, intense treatment options including allogeneic stem cell transplantation (Allo-SCT) are not feasible. New treatment options are emerging for this elderly/unfit treatment group, we therefore conducted a systematic review to determine whether they offered an advance on the existing recommended treatment, R-CHOP. The search strategies to identify MCL therapies were designed to capture the most relevant studies from 2013 to 2020. Following preferred reporting items for systematic reviews and meta-analyses and population,interventions, observations and study design analysis, R-CHOP, ibrutinib and bendamustine plus rituximab (BR) were taken forward for critical and statistical analysis. All three therapies were effective in increasing the overall survival (OS) and progression-free survival of elderly/unfit patients with MCL. However, none resulted in a significant increase in OS compared to R-CHOP. In addition, R-CHOP had a better toxicity profile when compared to both ibrutinib and BR. We therefore conclude that treatment of elderly/unfit patients with MCL is still a significant unmet clinical need; and suggest that outside of the clinical trial setting, R-CHOP should remain the recommended front-line treatment for this patient group.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | MCL, R‐CHOP, elderly, ibrutinib, treatment |
| Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Systems, Molecular and Integrative Biology Faculty of Science and Engineering > School of Physical Sciences |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 10 Nov 2021 09:18 |
| Last Modified: | 06 Dec 2024 19:37 |
| DOI: | 10.1002/jha2.311 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3142995 |
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