Gallbladder disease and pancreatic cancer risk: a multicentric case-control European study

Rosato, V, Gomez-Rubio, P, Molina-Montes, E, Marquez, M, Lohr, M, O'Rorke, M, Michalski, CW, Molero, X, Farre, A, Perea, J
et al (show 25 more authors) (2021) Gallbladder disease and pancreatic cancer risk: a multicentric case-control European study. EUROPEAN JOURNAL OF CANCER PREVENTION, 30 (6). pp. 423-430.

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<h4>Background and aims</h4>The overall evidence on the association between gallbladder conditions (GBC: gallstones and cholecystectomy) and pancreatic cancer (PC) is inconsistent. To our knowledge, no previous investigations considered the role of tumour characteristics on this association. Thus, we aimed to assess the association between self-reported GBC and PC risk, by focussing on timing to PC diagnosis and tumour features (stage, location, and resection).<h4>Methods</h4>Data derived from a European case-control study conducted between 2009 and 2014 including 1431 PC cases and 1090 controls. We used unconditional logistic regression models to estimate odds ratios (ORs) and corresponding 95% confidence intervals (CIs) adjusted for recognized confounders.<h4>Results</h4>Overall, 298 (20.8%) cases and 127 (11.6%) controls reported to have had GBC, corresponding to an OR of 1.70 (95% CI 1.33-2.16). The ORs were 4.84 (95% CI 2.96-7.89) for GBC diagnosed <3 years before PC and 1.06 (95% CI 0.79-1.41) for ≥3 years. The risk was slightly higher for stage I/II (OR = 1.71, 95% CI 1.15-2.55) vs. stage III/IV tumours (OR = 1.23, 95% CI 0.87-1.76); for tumours sited in the head of the pancreas (OR = 1.59, 95% CI 1.13-2.24) vs. tumours located at the body/tail (OR = 1.02, 95% CI 0.62-1.68); and for tumours surgically resected (OR = 1.69, 95% CI 1.14-2.51) vs. non-resected tumours (OR = 1.25, 95% CI 0.88-1.78). The corresponding ORs for GBC diagnosed ≥3 years prior PC were close to unity.<h4>Conclusion</h4>Our study supports the association between GBC and PC. Given the time-risk pattern observed, however, this relationship may be non-causal and, partly or largely, due to diagnostic attention and/or reverse causation.

Item Type: Article
Uncontrolled Keywords: case-control study, cholecystectomy, gallbladder condition, gallstones, pancreatic cancer risk
Divisions: Faculty of Health and Life Sciences
Faculty of Health and Life Sciences > Institute of Systems, Molecular and Integrative Biology
Depositing User: Symplectic Admin
Date Deposited: 17 Nov 2021 09:54
Last Modified: 18 Jan 2023 21:24
DOI: 10.1097/CEJ.0000000000000588
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