Persistence of G10P[11] neonatal rotavirus infections in southern India

Babji, Sudhir, Sindhu, Kulandaipalayam Natarajan, Selvarajan, Sribal, Ramani, Sasirekha, Venugopal, Srinivasan, Khakha, Shainey Alokit, Hemavathy, Priya, Ganesan, Santhosh Kumar, Giri, Sidhartha, Reju, Sudhabharathi
et al (show 5 more authors) (2021) Persistence of G10P[11] neonatal rotavirus infections in southern India. JOURNAL OF CLINICAL VIROLOGY, 144. 104989-.

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<h4>Background</h4>Neonatal rotavirus infections are predominantly caused by distinct genotypes restricted to this age-group and are mostly asymptomatic.<h4>Method</h4>Stool samples from neonates admitted for >48 h in neonatal intensive care units (NICUs) in Vellore (2014-2015) and Chennai (2015-2016) in southern India, and from neonates born at hospitals in Vellore but not admitted to NICUs (2015-2016) were tested for rotavirus by ELISA and genotyped by hemi-nested RT-PCR.<h4>Results</h4>Of 791 neonates, 150 and 336 were recruited from Vellore and Chennai NICUs, and 305 were born in five hospitals in Vellore. Positivity rates in the three settings were 49.3% (74/150), 29.5% (99/336) and 54% (164/305), respectively. G10P[11] was the commonly identified genotype in 87.8% (65/74), 94.9% (94/99) and 98.2% (161/164) of the neonates in Vellore and Chennai NICUs, and those born at Vellore hospitals, respectively. Neonates delivered by lower segment cesarian section (LSCS) at Vellore hospitals, not admitted to NICUs, had a significantly higher odds of acquiring rotavirus infection compared to those delivered vaginally [p = 0.002, OR = 2.4 (1.4-4.3)].<h4>Conclusions</h4>This report demonstrates the persistence of G10P[11] strain in Vellore and Chennai, indicating widespread neonatal G10P[11] strain in southern India and their persistence over two decades, leading to interesting questions about strain stability.

Item Type: Article
Uncontrolled Keywords: Rotavirus infection, Neonate, Nursery, G10P[11] strain
Divisions: Faculty of Health and Life Sciences
Faculty of Health and Life Sciences > Institute of Infection, Veterinary and Ecological Sciences
Depositing User: Symplectic Admin
Date Deposited: 31 Jan 2022 14:47
Last Modified: 18 Jan 2023 21:24
DOI: 10.1016/j.jcv.2021.104989
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