Serum protein signatures differentiate paediatric autoimmune/ inflammatory disorders

Carlsson, Emil, Midgley, Angela, Perkins, Simon, Caamano-Gutierrez, Eva ORCID: 0000-0001-7737-5941, Gritzfeld, Jenna F, Beresford, Michael W and Hedrich, Christian M ORCID: 0000-0002-1295-6179 (2021) Serum protein signatures differentiate paediatric autoimmune/ inflammatory disorders. CLINICAL IMMUNOLOGY, 229. 108790-.

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Abstract

Because of their rarity, limited awareness among non-specialists, and significant overlaps in their clinical presentation, childhood autoimmune/inflammatory conditions represent a diagnostic and therapeutic challenge. Juvenile idiopathic arthritis (JIA), with its 7 sub-forms, is the most common paediatric "rheumatic" disease. Juvenile-onset systemic lupus erythematosus (jSLE) is a severe autoimmune/inflammatory disease that can affect any organ system and shares clinical features with JIA. To overcome issues around diagnostic approaches in the context of clinical overlap, we aimed at the definition of disease sub-form specific cytokine and chemokine profiles. Serum samples from patients with JIA (n = 77) and jSLE (n = 48), as well as healthy controls (n = 30), were collected. Samples were analysed using the Meso Scale Discovery (MSD) U-PLEX Biomarker Group 1 (hu) panel. Distinct serum protein signatures associate with JIA vs jSLE disease groups. Proteins with high discriminatory ability include IL-23, MIP-1β, MCP-1, M-CSF and MDC. Furthermore, serum IL-18, MIF, MIP-5 and YKL-40 discriminate between systemic JIA and other JIA subtypes. Thus, simultaneous quantification of serum proteins in a panel format may provide an avenue for the diagnosis and monitoring of childhood autoimmune/inflammatory conditions.

Item Type:	Article
Uncontrolled Keywords:	Juvenile idiopathic arthritis, Systemic lupus erythematosus, Juvenile, Biomarker, Inflammation, Childhood, Paediatric
Divisions:	Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences Faculty of Health and Life Sciences > Tech, Infrastructure and Environmental Directorate
Depositing User:	Symplectic Admin
Date Deposited:	26 Nov 2021 09:28
Last Modified:	18 Jan 2023 21:24
DOI:	10.1016/j.clim.2021.108790
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3143908