Harwood, Rachel 
ORCID: 0000-0003-3440-3142, Allin, Benjamin, Jones, Christine, Whittaker, Elizabeth, Ramnarayan, Padmanabhan ORCID: 0000-0003-0784-8154, Ramanan, Athimalaipet ORCID: 0000-0001-8663-2401, Kaleem, Musa, Tulloh, Robert ORCID: 0000-0002-3180-6993, Peters, Mark ORCID: 0000-0003-3653-4808, Almond, Sarah et al (show 5 more authors)
(2020)
A national consensus management pathway for Paediatric Inflammatory Multisystem Syndrome - Temporally associated with SARS-CoV-2 (PIMS-TS): The results of a national Delphi process
MedRxiv.
2020.07.17.20156075-.
ISSN 3067-2007
Abstract
<h4>Objective</h4> To develop a consensus management pathway for children with Paediatric Inflammatory Multisystem Syndrome - Temporally associated with SARS-CoV-2 (PIMS-TS). <h4>Design</h4> A three-phase online Delphi process and virtual consensus meeting sought consensus over the investigation, management and research priorities from 98 multidisciplinary participants caring for children with PIMS-TS. 46 participants (47%) completed all three phases. Participants were grouped into three panels and scored each statement from 1 (disagree) to 9 (strongly agree). In phase two participants were shown their panel’s scores, and in phase three all panels’ scores. Consensus agreement was defined as ≥70% of participants in each panel scoring the statement 7-9, and <15% scoring 1-3, and consensus disagreement was the opposite of this. Statements which achieved consensus in 2/3 panels were discussed at the consensus meeting, and when ≥70% participants agreed with the statement it achieved consensus. <h4>Results</h4> 255 statements were assessed, with ‘consensus agreement’ achieved for 111 (44%), ‘consensus disagreement’ for 29 (11%), and no consensus for 115 (45%). The 140 consensus statements were used to derive the consensus management pathway. <h4>Conclusions</h4> A national consensus pathway has been developed for children suspected of having the novel syndrome PIMS-TS in a timely, cost-efficient manner, in the midst of a global pandemic. Use of a rapid online Delphi process has made this consensus process possible. Future evidence will inform updates to this guidance, which in the interim provides a solid framework to support clinicians caring for children with PIMS-TS.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | 4201 Allied Health and Rehabilitation Science, 42 Health Sciences, Clinical Research, Pediatric Research Initiative |
| Divisions: | Faculty of Health & Life Sciences Faculty of Health & Life Sciences > Inst. Infection, Vet & Ecological Sciences Faculty of Health & Life Sciences > Inst. Systems, Molec & Integrative Biology > Inst. Systems, Molec & Integrative Biology |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 30 Nov 2021 08:46 |
| Last Modified: | 03 Jul 2026 09:30 |
| DOI: | 10.1101/2020.07.17.20156075 |
| Open Access URL: | https://www.medrxiv.org/content/10.1101/2020.07.17... |
| Related Websites: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3144196 |
| Disclaimer: | The University of Liverpool is not responsible for content contained on other websites from links within repository metadata. Please contact us if you notice anything that appears incorrect or inappropriate. |
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