Care, Angharad G 
ORCID: 0000-0003-2131-0406, Gupta, Juhi K ORCID: 0000-0002-8292-9846, Goodfellow, Laura ORCID: 0000-0002-8111-5007, Zhang, Ge, Monangi, Nagendra, Belling, Elizabeth, Landero, Julio, Chappell, Joanne, Sharp, Andrew ORCID: 0000-0003-3396-7464, Alfirevic, Ana ORCID: 0000-0002-2801-9817 et al (show 3 more authors)
(2021)
Maternal selenium levels and whole genome screen in recurrent spontaneous preterm birth population: a nested case control study.
European Journal of Obstetrics & Gynecology and Reproductive Biology, 265.
pp. 203-211.
Abstract
<h4>Objective</h4>To establish if low maternal selenium (Se) was associated with sPTB in women with recurrent sPTB and identify genetic link with maternal Se levels.<h4>Design</h4>Nested case-control study.<h4>Setting</h4>Tertiary Maternity Hospital.<h4>Population</h4>Plasma and whole blood from pregnant women with history of early sPTB/PPROM < 34<sup>+0</sup> and European ancestry were obtained at 20 weeks (range 15-24 weeks). 'Cases' were recurrent PTB/PPROM < 34<sup>+0</sup> weeks and term (≥37<sup>+0</sup>) deliveries were classified as 'high-risk controls.' Women with previous term births and index birth ≥ 39 weeks were 'low-risk controls'.<h4>Methods</h4>Maternal plasma Se measured by ICP-MS was used as a continuous phenotype in a GWAS analysis. Se was added to a logistic regression model using PTB predictor variables.<h4>Main outcome measures</h4>Maternal Se concentration, recurrent early sPTB/PPROM.<h4>Results</h4>53/177 high-risk women had a recurrent sPTB/PPROM < 34<sup>+0</sup>weeks and were 2.7 times more likely to have a Se level < 83.3 ppm at 20weeks of pregnancy compared with low-risk term controls (n = 179), (RR 2.7, 95%CI 1.5-4.8; p = .001). One SNP from a non-coding region (FOXN3 intron variant, rs55793422) reached genome-wide significance level (p = 3.73E<sup>-08</sup>). Targeted analysis of Se gene variant did not show difference between preterm and term births. (χ<sup>2</sup> test, OR = 0.95; 95%CI = 0.59-1.56; p = 0.82). When Se levels were added to a clinical prediction model, only an additional 5% of cases (n = 3) and 0.6% (n = 1) of controls were correctly identified.<h4>Conclusions</h4>Low plasma Se is associated with sPTB risk but is not sufficiently predictive at individual patient level. We did not find a genetic association between maternal Se levels and Se-related genes.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Genome wide association study, Nutrition, Obstetrics, Preterm birth, Selenium |
| Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences Faculty of Health and Life Sciences > Institute of Population Health Faculty of Health and Life Sciences > Institute of Systems, Molecular and Integrative Biology |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 09 Dec 2021 10:16 |
| Last Modified: | 18 Jan 2023 21:23 |
| DOI: | 10.1016/j.ejogrb.2021.08.015 |
| Open Access URL: | https://doi.org/10.1016/j.ejogrb.2021.08.015 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3145053 |
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