Smoking Cessation after Diagnosis of New-Onset Atrial Fibrillation and the Risk of Stroke and Death



Lee, So-Ryoung, Choi, Eue-Keun, Jung, Jin-Hyung, Han, Kyung-Do, Oh, Seil and Lip, Gregory YH ORCID: 0000-0002-7566-1626
(2021) Smoking Cessation after Diagnosis of New-Onset Atrial Fibrillation and the Risk of Stroke and Death. JOURNAL OF CLINICAL MEDICINE, 10 (11). 2238-.

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Abstract

Limited data are available regarding the impact of smoking cessation after atrial fibrillation (AF) diagnosis on clinical outcomes. Using the Korean National Health Insurance Service database, we included patients newly diagnosed with AF and categorized them into four groups as follows: (i) never smokers, (ii) ex-smokers, (iii) smoking cessation after AF diagnosis ("quitters"), and (iv) current smokers. The primary outcomes were incident ischemic stroke and all-cause death during follow-up. Fatal ischemic stroke and death from cerebrovascular events were evaluated as secondary outcomes. Among 97,637 patients (mean age, 61 years; mean CHA<sub>2</sub>DS<sub>2</sub>-VASc score, 2.3), 6.9% stopped smoking after AF diagnosis. The mean follow-up duration was 3.2 ± 2.0 years. After multivariable adjustment, quitters had lower risks of ischemic stroke (hazard ratio (HR), 0.702; 95% confidence interval (CI), 0.595-0.827) and all-cause death (HR, 0.842; 95% CI, 0.748-0.948) than current smokers. Quitters after AF diagnosis were associated with lower risks of fatal ischemic stroke (HR, 0.454; 95% CI, 0.287-0.718) and death from cerebrovascular events (HR, 0.664; 95% CI, 0.465-0.949) compared with current smokers. Quitting smoking may reduce the risk of ischemic stroke, the severity of ischemic stroke, and the incidence of cerebrovascular events in patients with new-onset AF.

Item Type: Article
Uncontrolled Keywords: smoking, atrial fibrillation, stroke, death
Divisions: Faculty of Health and Life Sciences
Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences
Depositing User: Symplectic Admin
Date Deposited: 21 Dec 2021 12:52
Last Modified: 01 Feb 2024 00:45
DOI: 10.3390/jcm10112238
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3145770