CD8 T cell-mediated cerebellitis directed against Purkinje cell antigen after ipilimumab for small cell lung cancer



Hardwick, Marc, Nolan, Luke, Nicoll, James, Jogai, Sanjay, Arriola, Edurne, Joseph-Pietras, Debora, Ottensmeier, Christian ORCID: 0000-0003-3619-1657 and Galea, Ian
(2021) CD8 T cell-mediated cerebellitis directed against Purkinje cell antigen after ipilimumab for small cell lung cancer. JOURNAL OF THE NEUROLOGICAL SCIENCES, 429 (2). pp. 30-31.

Access the full-text of this item by clicking on the Open Access link.

Abstract

We report a rapidly progressive and fatal CD8 T-cell-mediated cerebellitis after ipilimumab (cytotoxic T-lymphocyte-associated protein 4 inhibitor) for small cell lung cancer. Clinical features and histopathology were consistent with an accelerated form of paraneoplastic cerebellar degeneration. A patchy CD8 T-cell infiltrate spatially corresponded to areas of Purkinje cell loss, with occasional CD8 polarisation towards Purkinje cells. CD20-positive B cells were sparse. CD8 T-cell-mediated cerebellitis after immune checkpoint inhibitor treatment may recapitulate the early stages of paraneoplastic cerebellar degeneration.

Item Type: Article
Uncontrolled Keywords: CD8 T cells, cerebellitis, CTLA-4 inhibitor, immune checkpoint inhibitors, ipilimumab, paraneoplastic cerebellar degeneration
Divisions: Faculty of Health and Life Sciences
Faculty of Health and Life Sciences > Institute of Systems, Molecular and Integrative Biology
Depositing User: Symplectic Admin
Date Deposited: 22 Dec 2021 09:34
Last Modified: 18 Jan 2023 21:18
DOI: 10.1016/j.jns.2021.118843
Open Access URL: https://onlinelibrary.wiley.com/doi/10.1111/nan.12...
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3145788