Hardwick, Marc, Nolan, Luke, Nicoll, James, Jogai, Sanjay, Arriola, Edurne, Joseph-Pietras, Debora, Ottensmeier, Christian ORCID: 0000-0003-3619-1657 and Galea, Ian
(2021)
CD8 T cell-mediated cerebellitis directed against Purkinje cell antigen after ipilimumab for small cell lung cancer.
JOURNAL OF THE NEUROLOGICAL SCIENCES, 429 (2).
pp. 30-31.
Abstract
We report a rapidly progressive and fatal CD8 T-cell-mediated cerebellitis after ipilimumab (cytotoxic T-lymphocyte-associated protein 4 inhibitor) for small cell lung cancer. Clinical features and histopathology were consistent with an accelerated form of paraneoplastic cerebellar degeneration. A patchy CD8 T-cell infiltrate spatially corresponded to areas of Purkinje cell loss, with occasional CD8 polarisation towards Purkinje cells. CD20-positive B cells were sparse. CD8 T-cell-mediated cerebellitis after immune checkpoint inhibitor treatment may recapitulate the early stages of paraneoplastic cerebellar degeneration.
Item Type: | Article |
---|---|
Uncontrolled Keywords: | CD8 T cells, cerebellitis, CTLA-4 inhibitor, immune checkpoint inhibitors, ipilimumab, paraneoplastic cerebellar degeneration |
Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Systems, Molecular and Integrative Biology |
Depositing User: | Symplectic Admin |
Date Deposited: | 22 Dec 2021 09:34 |
Last Modified: | 18 Jan 2023 21:18 |
DOI: | 10.1016/j.jns.2021.118843 |
Open Access URL: | https://onlinelibrary.wiley.com/doi/10.1111/nan.12... |
Related URLs: | |
URI: | https://livrepository.liverpool.ac.uk/id/eprint/3145788 |