CD4<sup>+</sup> follicular helper-like T cells are key players in anti-tumor immunity



Singh, D, Ganesan, AP, Panwar, B, Eschweiler, S, Hanley, CJ ORCID: 0000-0003-3816-7220, Madrigal, A, Ramírez-Suástegui, C, Wang, A, Clarke, J, Wood, O
et al (show 13 more authors) (2020) CD4<sup>+</sup> follicular helper-like T cells are key players in anti-tumor immunity. Journal of Clinical Investigation.

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Abstract

<h4>ABSTRACT</h4> To determine the nature of CD4 + T cells that provide ‘help’ for generating robust anti-tumor CD8 + cytotoxic T cell (CTL) responses, we profiled the transcriptomes of patient-matched CD4 + and CD8 + T cells present in the tumor micro-environment (TME) and analyzed them jointly using integrated weighted gene correlation network analysis. We found the follicular helper T cell (T FH ) program in CD4 + T cells was strongly associated with proliferation and tissue-residency in CD8 + CTLs. Single-cell analysis demonstrated the presence of T FH -like cells and features linked to cytotoxic function and their provision of CD8 + T cell ‘help’. Tumor-infiltrating T FH -like cells expressed PD-1 and were enriched in tumors following checkpoint blockade, suggesting that they may respond to anti-PD-1 therapy. Adoptive transfer or induction of T FH cells in mouse models resulted in augmented CD8 + CTL responses and impairment of tumor growth, indicating an important role of T FH -like CD4 + T cells in anti-tumor immunity.

Item Type: Article
Divisions: Faculty of Health and Life Sciences
Faculty of Health and Life Sciences > Institute of Systems, Molecular and Integrative Biology
Depositing User: Symplectic Admin
Date Deposited: 22 Dec 2021 09:20
Last Modified: 18 Jan 2023 21:18
DOI: 10.1101/2020.01.08.898346
Open Access URL: https://www.biorxiv.org/content/10.1101/2020.01.08...
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3145818