Dvorak, Vojtech, Wiedmer, Tabea, Ingles-Prieto, Alvaro, Altermatt, Patrick, Batoulis, Helena, Baerenz, Felix, Bender, Eckhard, Digles, Daniela, Durrenberger, Franz, Heitman, Laura H et al (show 21 more authors)
(2021)
An Overview of Cell-Based Assay Platforms for the Solute Carrier Family of Transporters.
FRONTIERS IN PHARMACOLOGY, 12.
722889-.
ISSN 1663-9812, 1663-9812
Abstract
The solute carrier (SLC) superfamily represents the biggest family of transporters with important roles in health and disease. Despite being attractive and druggable targets, the majority of SLCs remains understudied. One major hurdle in research on SLCs is the lack of tools, such as cell-based assays to investigate their biological role and for drug discovery. Another challenge is the disperse and anecdotal information on assay strategies that are suitable for SLCs. This review provides a comprehensive overview of state-of-the-art cellular assay technologies for SLC research and discusses relevant SLC characteristics enabling the choice of an optimal assay technology. The Innovative Medicines Initiative consortium RESOLUTE intends to accelerate research on SLCs by providing the scientific community with high-quality reagents, assay technologies and data sets, and to ultimately unlock SLCs for drug discovery.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | solute carrier, cell-based assay, drug discovery, chemical screening, transporters, SLC |
| Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Systems, Molecular and Integrative Biology |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 23 Dec 2021 08:34 |
| Last Modified: | 06 Dec 2024 20:55 |
| DOI: | 10.3389/fphar.2021.722889 |
| Open Access URL: | https://doi.org/10.3389/fphar.2021.722889 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3145936 |
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