Chemical Modification of Glycosaminoglycan Polysaccharides

Palhares, Lais CGF, London, James A ORCID: 0000-0002-5823-7057, Kozlowski, Aleksandra M, Esposito, Emiliano, Chavante, Suely F, Ni, Minghong and Yates, Edwin A ORCID: 0000-0001-9365-5433
(2021) Chemical Modification of Glycosaminoglycan Polysaccharides. MOLECULES, 26 (17). 5211-.

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The linear anionic class of polysaccharides, glycosaminoglycans (GAGs), are critical throughout the animal kingdom for developmental processes and the maintenance of healthy tissues. They are also of interest as a means of influencing biochemical processes. One member of the GAG family, heparin, is exploited globally as a major anticoagulant pharmaceutical and there is a growing interest in the potential of other GAGs for diverse applications ranging from skin care to the treatment of neurodegenerative conditions, and from the treatment and prevention of microbial infection to biotechnology. To realize the potential of GAGs, however, it is necessary to develop effective tools that are able to exploit the chemical manipulations to which GAGs are susceptible. Here, the current knowledge concerning the chemical modification of GAGs, one of the principal approaches for the study of the structure-function relationships in these molecules, is reviewed. Some additional methods that were applied successfully to the analysis and/or processing of other carbohydrates, but which could be suitable in GAG chemistry, are also discussed.

Item Type: Article
Uncontrolled Keywords: glycosaminoglycans, polysaccharides, sulfation, chemical modification
Divisions: Faculty of Health and Life Sciences
Faculty of Health and Life Sciences > Institute of Systems, Molecular and Integrative Biology
Depositing User: Symplectic Admin
Date Deposited: 23 Dec 2021 08:34
Last Modified: 18 Jan 2023 21:18
DOI: 10.3390/molecules26175211
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