Norris, T 
ORCID: 0000-0002-9140-0776, Razieh, C, Zaccardi, F, Yates, T, Islam, N, Gillies, CL, Chudasama, YV, Rowlands, AV, Davies, MJ, McCann, GP ORCID: 0000-0002-5542-8448 et al (show 8 more authors)
(2022)
Impact of cardiometabolic multimorbidity and ethnicity on cardiovascular/renal complications in patients with COVID-19
Heart, 108 (15).
pp. 1200-1208.
ISSN 1355-6037, 1468-201X
Abstract
Objective Using a large national database of people hospitalised with COVID-19, we investigated the contribution of cardio-metabolic conditions, multimorbidity and ethnicity on the risk of in-hospital cardiovascular complications and death. Methods A multicentre, prospective cohort study in 302 UK healthcare facilities of adults hospitalised with COVID-19 between 6 February 2020 and 16 March 2021. Logistic models were used to explore associations between baseline patient ethnicity, cardiometabolic conditions and multimorbidity (0, 1, 2, >2 conditions), and in-hospital cardiovascular complications (heart failure, arrhythmia, cardiac ischaemia, cardiac arrest, coagulation complications, stroke), renal injury and death. Results Of 65 624 patients hospitalised with COVID-19, 44 598 (68.0%) reported at least one cardiometabolic condition on admission. Cardiovascular/ renal complications or death occurred in 24 609 (38.0%) patients. Baseline cardiometabolic conditions were independently associated with increased odds of in-hospital complications and this risk increased in the presence of cardiometabolic multimorbidity. For example, compared with having no cardiometabolic conditions, 1, 2 or ≥3 conditions was associated with 1.46 (95% CI 1.39 to 1.54), 2.04 (95% CI 1.93 to 2.15) and 3.10 (95% CI 2.92 to 3.29) times higher odds of any cardiovascular/renal complication, respectively. A similar pattern was observed for all-cause death. Compared with the white group, the South Asian (OR 1.19, 95% CI 1.10 to 1.29) and black (OR 1.53 to 95% CI 1.37 to 1.72) ethnic groups had higher risk of any cardiovascular/renal complication. Conclusions In hospitalised patients with COVID-19, cardiovascular complications or death impacts just under half of all patients, with the highest risk in those of South Asian or Black ethnicity and in patients with cardiometabolic multimorbidity.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | COVID-19, epidemiology, risk factors |
| Divisions: | Faculty of Health & Life Sciences Faculty of Health & Life Sciences > Inst. Infection, Vet & Ecological Sciences |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 10 Jan 2022 14:31 |
| Last Modified: | 22 Jan 2026 23:39 |
| DOI: | 10.1136/heartjnl-2021-320047 |
| Open Access URL: | http://dx.doi.org/10.1136/heartjnl-2021-320047 |
| Related Websites: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3146129 |
| Disclaimer: | The University of Liverpool is not responsible for content contained on other websites from links within repository metadata. Please contact us if you notice anything that appears incorrect or inappropriate. |
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