Clinical findings associated with N-terminal pro-B-type natriuretic peptide measurement in dogs and cats attending first opinion veterinary practices

O'Shaughnessy, Sarah, Crawford, India, Arsevska, Elena, Singleton, David, Hughes, David, Noble, Peter-John ORCID: 0000-0002-2275-2014 and Hezzell, Melanie (2022) Clinical findings associated with N-terminal pro-B-type natriuretic peptide measurement in dogs and cats attending first opinion veterinary practices VETERINARY RECORD, 191 (2). e945-. ISSN 0042-4900, 2042-7670

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Abstract

Background: Clinical findings associated with N-terminal pro-B-type natriuretic peptide (NT-proBNP) measurement in dogs and cats in primary practice, and their relevance to published measurement indications, have not been described. Methods: Using electronic health record data collected by the Small Animal Veterinary Surveillance Network, appointments in which NT-proBNP was measured were identified using keyword-based text filtering. For these appointments, clinical findings were manually identified from each patient's clinical narrative (CN) and their frequencies described. Results: CNs of 3510 appointments (357 dogs and 257 cats) from 99practices were evaluated. The most frequently recorded clinical findings in dogs were: heart murmur (n = 147, 41.2% (95% confidence interval (CI) = 36.1%–46.3%), coughing (n = 83, 23.2% (95% CI = 18.8%–27.6%)) and panting (n = 58, 16.2% (95% CI = 12.4%–20.0%)) and in cats: heart murmur (n = 143, 55.6% (95% CI = 49.5%–61.7%)), suspected thromboembolism (n = 88, 34.2% (95% CI = 28.4%–40.0%)) and weight loss (n = 53, 20.6% (95% CI = 15.7%–25.5%)). Dyspnoea and tachypnoea were infrequently reported in dogs (n = 29, 8.1% (95% CI = 5.3%–10.9%) and n = 21, 5.9% (95% CI = 3.5%–8.3%), respectively) and cats (n = 26, 10.1% (95% CI = 6.4%–13.8%) and n = 36, 14.0% (95% CI = 9.8%–18.2%), respectively). Conclusion: Clinical findings referable to cardiac disease were recorded contemporaneously with NT-proBNP measurement and suggested both published and other indications (coughing (in dogs and cats), and serial measurements and thromboembolism (in cats)) for testing.

Item Type:	Article
Uncontrolled Keywords:	Animals, Dogs, Cats, Heart Murmurs, Thromboembolism, Cat Diseases, Dog Diseases, Natriuretic Peptide, Brain, Peptide Fragments, Biomarkers
Divisions:	Faculty of Health & Life Sciences Faculty of Health & Life Sciences > Inst. Infection, Vet & Ecological Sciences
Depositing User:	Symplectic Admin
Date Deposited:	20 Jan 2022 08:41
Last Modified:	16 Jun 2026 09:24
DOI:	10.1002/vetr.945
Related Websites:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3147190
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