Optimising antimicrobial use in humans – review of current evidence and an interdisciplinary consensus on key priorities for research

Collapse authors list.
Charani, E ORCID: 0000-0002-5938-1202, McKee, M, Ahmad, R, Balasegaram, M, Bonaconsa, C, Merrett, GB, Busse, R, Carter, V, Castro-Sanchez, E, Franklin, BD ORCID: 0000-0002-2892-1245 et al (show 18 more authors) , Georgiou, P, Hill-Cawthorne, K ORCID: 0000-0001-8663-8790, Hope, W ORCID: 0000-0001-6187-878X, Imanaka, Y, Kambugu, A, Leather, AJ, Mbamalu, O, McLeod, M ORCID: 0000-0001-5571-2417, Mendelson, M, Mpundu, M, Rawson, TM ORCID: 0000-0002-2630-9722, Ricciardi, W, Rodriguez-Manzano, J ORCID: 0000-0002-2583-8366, Singh, S, Tsioutis, C, Uchea, C ORCID: 0000-0003-2847-813X, Zhu, N and Holmes, AH ORCID: 0000-0001-5554-5743 (2021) Optimising antimicrobial use in humans – review of current evidence and an interdisciplinary consensus on key priorities for research Lancet Regional Health Europe, 7. 100161-. ISSN 2666-7762, 2666-7762

Access the full-text of this item by clicking on the Open Access link.

Abstract

Addressing the silent pandemic of antimicrobial resistance (AMR) is a focus of the 2021 G7 meeting. A major driver of AMR and poor clinical outcomes is suboptimal antimicrobial use. Current research in AMR is inequitably focused on new drug development. To achieve antimicrobial security we need to balance AMR research efforts between development of new agents and strategies to preserve the efficacy and maximise effectiveness of existing agents. Combining a review of current evidence and multistage engagement with diverse international stakeholders (including those in healthcare, public health, research, patient advocacy and policy) we identified research priorities for optimising antimicrobial use in humans across four broad themes: policy and strategic planning; medicines management and prescribing systems; technology to optimise prescribing; and context, culture and behaviours. Sustainable progress depends on: developing economic and contextually appropriate interventions; facilitating better use of data and prescribing systems across healthcare settings; supporting appropriate and scalable technological innovation. Implementing this strategy for AMR research on the optimisation of antimicrobial use in humans could contribute to equitable global health security.

Item Type:	Article
Uncontrolled Keywords:	32 Biomedical and Clinical Sciences, 3202 Clinical Sciences, Infectious Diseases, Emerging Infectious Diseases, 8.3 Policy, ethics, and research governance, 8.1 Organisation and delivery of services, Infection, Generic health relevance
Divisions:	Faculty of Health & Life Sciences Faculty of Health & Life Sciences > Inst. Systems, Molec & Integrative Biology > Inst. Systems, Molec & Integrative Biology
Depositing User:	Symplectic Admin
Date Deposited:	27 Jan 2022 09:14
Last Modified:	23 Jan 2026 10:14
DOI:	10.1016/j.lanepe.2021.100161
Open Access URL:	https://doi.org/10.1016/j.lanepe.2021.100161
Related Websites:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3147676
Disclaimer:	The University of Liverpool is not responsible for content contained on other websites from links within repository metadata. Please contact us if you notice anything that appears incorrect or inappropriate.