Carriage Dynamics of Pneumococcal Serotypes in Naturally Colonized Infants in a Rural African Setting During the First Year of Life


Chaguza, Chrispin ORCID: 0000-0002-2108-1757, Senghore, Madikay, Bojang, Ebrima, Lo, Stephanie W, Ebruke, Chinelo, Gladstone, Rebecca A, Tientcheu, Peggy-Estelle, Bancroft, Rowan E, Worwui, Archibald, Foster-Nyarko, Ebenezer et al (show 10 more authors) (2021) Carriage Dynamics of Pneumococcal Serotypes in Naturally Colonized Infants in a Rural African Setting During the First Year of Life. FRONTIERS IN PEDIATRICS, 8. 587730-.

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Abstract

<i>Streptococcus pneumoniae</i> (the pneumococcus) carriage precedes invasive disease and influences population-wide strain dynamics, but limited data exist on temporal carriage patterns of serotypes due to the prohibitive costs of longitudinal studies. Here, we report carriage prevalence, clearance and acquisition rates of pneumococcal serotypes sampled from newborn infants bi-weekly from weeks 1 to 27, and then bi-monthly from weeks 35 to 52 in the Gambia. We used sweep latex agglutination and whole genome sequencing to serotype the isolates. We show rapid pneumococcal acquisition with nearly 31% of the infants colonized by the end of first week after birth and quickly exceeding 95% after 2 months. Co-colonization with multiple serotypes was consistently observed in over 40% of the infants at each sampling point during the first year of life. Overall, the mean acquisition time and carriage duration regardless of serotype was 38 and 24 days, respectively, but varied considerably between serotypes comparable to observations from other regions. Our data will inform disease prevention and control measures including providing baseline data for parameterising infectious disease mathematical models including those assessing the impact of clinical interventions such as pneumococcal conjugate vaccines.

Item Type: Article
Uncontrolled Keywords: pneumococcus, serotype, carriage duration, acquisition, Africa, infants
Divisions: Faculty of Health and Life Sciences
Faculty of Health and Life Sciences > Institute of Infection, Veterinary and Ecological Sciences
Depositing User: Symplectic Admin
Date Deposited: 27 Jan 2022 13:54
Last Modified: 18 Jan 2023 21:14
DOI: 10.3389/fped.2020.587730
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3147704
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