Corneal Endothelial Cell Loss in Glaucoma and Glaucoma Surgery and the Utility of Management with Descemet Membrane Endothelial Keratoplasty (DMEK)

Vallabh, Neeru A ORCID: 0000-0002-0109-4112, Kennedy, Stephnie, Vinciguerra, Riccardo, McLean, Keri ORCID: 0000-0002-8907-1176, Levis, Hannah ORCID: 0000-0002-3923-1178, Borroni, Davide ORCID: 0000-0001-6952-5647, Romano, Vito ORCID: 0000-0002-5148-7643 and Willoughby, Colin E (2022) Corneal Endothelial Cell Loss in Glaucoma and Glaucoma Surgery and the Utility of Management with Descemet Membrane Endothelial Keratoplasty (DMEK) Journal of Ophthalmology, 2022 (1). pp. 1-17. ISSN 2090-004X, 2090-0058

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Abstract

The corneal endothelium has a crucial role in maintaining a clear and healthy cornea. Corneal endothelial cell loss occurs naturally with age; however, a diagnosis of glaucoma and surgical intervention for glaucoma can exacerbate a decline in cell number and impairment in morphology. In glaucoma, the mechanisms for this are not well understood, and this accelerated cell loss can result in corneal decompensation. Given the high prevalence of glaucoma worldwide, this review aims to explore the abnormalities observed in the corneal endothelium in differing glaucoma phenotypes and glaucoma therapies (medical or surgical, including with new generation microinvasive glaucoma surgeries). Descemet membrane endothelial keratoplasty (DMEK) is increasingly being used to manage corneal endothelial failure for glaucoma patients, and we aim to review the recent literature evaluating the use of this technique in this clinical scenario.

Item Type:	Article
Uncontrolled Keywords:	32 Biomedical and Clinical Sciences, 3212 Ophthalmology and Optometry, Transplantation, Eye Disease and Disorders of Vision, Aging, Neurodegenerative, Clinical Research, Neurosciences, 2.1 Biological and endogenous factors, 1.1 Normal biological development and functioning, Eye
Divisions:	Faculty of Health & Life Sciences Faculty of Health & Life Sciences > Clinical Directorate Faculty of Health & Life Sciences > Inst. Life Courses & Medical Sciences
Depositing User:	Symplectic Admin
Date Deposited:	01 Feb 2022 09:51
Last Modified:	01 Mar 2026 11:59
DOI:	10.1155/2022/1315299
Open Access URL:	https://doi.org/10.1155/2022/1315299
Related Websites:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3147941
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