Mandolo, Jonathan J, Henrion, Marc YR, Mhango, Chimwemwe, Chinyama, End, Wachepa, Richard, Kanjerwa, Oscar, Malamba-Banda, Chikondi, Shawa, Isaac T, Hungerford, Daniel 
ORCID: 0000-0002-9770-0163, Kamng'ona, Arox W ORCID: 0000-0002-0841-7586 et al (show 3 more authors)
(2021)
Reduction in Severity of All-Cause Gastroenteritis Requiring Hospitalisation in Children Vaccinated against Rotavirus in Malawi.
VIRUSES-BASEL, 13 (12).
2491-.
|
Text
Reduction in Severity of All-Cause Gastroenteritis Requiring Hospitalisation in Children Vaccinated against Rotavirus in Mal.pdf - Published version Download (1MB) | Preview |
Abstract
Rotavirus is the major cause of severe gastroenteritis in children aged <5 years. Introduction of the G1P[8] Rotarix<sup>®</sup> rotavirus vaccine in Malawi in 2012 has reduced rotavirus-associated hospitalisations and diarrhoeal mortality. However, the impact of rotavirus vaccine on the severity of gastroenteritis presented in children requiring hospitalisation remains unknown. We conducted a hospital-based surveillance study to assess the impact of Rotarix<sup>®</sup> vaccination on the severity of gastroenteritis presented by Malawian children. Stool samples were collected from children aged <5 years who required hospitalisation with acute gastroenteritis from December 2011 to October 2019. Gastroenteritis severity was determined using Ruuska and Vesikari scores. Rotavirus was detected using enzyme immunoassay. Rotavirus genotypes were determined using nested RT-PCR. Associations between Rotarix<sup>®</sup> vaccination and gastroenteritis severity were investigated using adjusted linear regression. In total, 3159 children were enrolled. After adjusting for mid-upper arm circumference (MUAC), age, gender and receipt of other vaccines, all-cause gastroenteritis severity scores were 2.21 units lower (<i>p</i> < 0.001) among Rotarix<sup>®</sup>-vaccinated (<i>n</i> = 2224) compared to Rotarix<sup>®</sup>-unvaccinated children (<i>n</i> = 935). The reduction in severity score was observed against every rotavirus genotype, although the magnitude was smaller among those infected with G12P[6] compared to the remaining genotypes (<i>p</i> = 0.011). Each one-year increment in age was associated with a decrease of 0.43 severity score (<i>p</i> < 0.001). Our findings provide additional evidence on the impact of Rotarix<sup>®</sup> in Malawi, lending further support to Malawi's Rotarix<sup>®</sup> programme.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | rotavirus, genotypes, Malawi, gastroenteritis, severity scores |
| Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Infection, Veterinary and Ecological Sciences |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 01 Feb 2022 10:06 |
| Last Modified: | 26 Jan 2023 05:11 |
| DOI: | 10.3390/v13122491 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3147942 |
Altmetric
Altmetric
