Skelly, Donal T, Harding, Adam C, Gilbert-Jaramillo, Javier, Knight, Michael L, Longet, Stephanie, Brown, Anthony, Adele, Sandra, Adland, Emily, Brown, Helen, Chinnakannan, Senthil et al (show 89 more authors)
(2021)
Two doses of SARS-CoV-2 vaccination induce robust immune responses to emerging SARS-CoV-2 variants of concern.
NATURE COMMUNICATIONS, 12 (1).
5061-.
Text
Two doses of SARS-CoV-2 vaccination induce robust immune responses to emerging SARS-CoV-2 variants of concern.pdf - Published version Download (2MB) | Preview |
Abstract
The extent to which immune responses to natural infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and immunization with vaccines protect against variants of concern (VOC) is of increasing importance. Accordingly, here we analyse antibodies and T cells of a recently vaccinated, UK cohort, alongside those recovering from natural infection in early 2020. We show that neutralization of the VOC compared to a reference isolate of the original circulating lineage, B, is reduced: more profoundly against B.1.351 than for B.1.1.7, and in responses to infection or a single dose of vaccine than to a second dose of vaccine. Importantly, high magnitude T cell responses are generated after two vaccine doses, with the majority of the T cell response directed against epitopes that are conserved between the prototype isolate B and the VOC. Vaccination is required to generate high potency immune responses to protect against these and other emergent variants.
Item Type: | Article |
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Uncontrolled Keywords: | Medawar Laboratory Team, OPTIC (Oxford Protective T cell Immunology for COVID-19) Clinical Group, PITCH (Protective Immunity T cells in Health Care Worker) Study Group, C-MORE/PHOSP-C Group, T-Lymphocytes, Animals, Humans, Carrier Proteins, Antibodies, Monoclonal, Antibodies, Viral, Epitopes, Immunity, Antibodies, Neutralizing, COVID-19, Angiotensin-Converting Enzyme 2, SARS-CoV-2, COVID-19 Vaccines |
Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Infection, Veterinary and Ecological Sciences |
Depositing User: | Symplectic Admin |
Date Deposited: | 03 Feb 2022 11:42 |
Last Modified: | 18 Jan 2023 21:14 |
DOI: | 10.1038/s41467-021-25167-5 |
Related URLs: | |
URI: | https://livrepository.liverpool.ac.uk/id/eprint/3148112 |