Onchocerca lupi in imported dogs in the UK: implications for animal and public health

McGarry, John W, Carrozza, Rossella, Bradley, Claire, Latrofa, Maria S, Makepeace, Benjamin L ORCID: 0000-0002-6100-6727 and Otranto, Domenico
(2022) Onchocerca lupi in imported dogs in the UK: implications for animal and public health. BMC Veterinary Research, 18 (1). 66-.

[img] Text
McGarry-2022.pdf - Published version

Download (1MB) | Preview


<jats:title>Abstract</jats:title><jats:sec> <jats:title>Background</jats:title> <jats:p><jats:italic>Onchocerca lupi</jats:italic> is a filarial nematode affecting dogs, and occasionally cats and humans, in continental Europe, North Africa, the Middle East, and the USA. Adult worms are usually found in periocular nodules and enucleation is sometimes required if the infection fails to respond to other treatment options.</jats:p> </jats:sec><jats:sec> <jats:title>Case presentation</jats:title> <jats:p>Here, we report the presence of <jats:italic>O. lupi</jats:italic> in the UK for the first time. Of two dogs re-homed from continental Europe, one developed an ocular nodule seven years after arrival from Portugal. The conjunctival perilimbal mass in its left eye was surgically removed but despite anthelminthic treatment, a further nodule developed in the same eye six months later. In the second case - a dog imported from Romania 12 months earlier - a perilimbal mass was excised from the left eye and prior anthelminthic treatment was supplemented with oral prednisolone and doxycycline. However, nodules recurred, and the left globe was subsequently enucleated. Conjunctival hyperaemia then appeared in the right eye and neither additional anthelminthic treatment nor removal of worm masses failed to prevent the further development of lesions. Excised adult worms were identified in both cases as <jats:italic>O. lupi</jats:italic> based on morphological characteristics, as well as PCR and sequencing of cytochrome <jats:italic>c</jats:italic> oxidase subunit I and 12S rRNA gene fragments.</jats:p> </jats:sec><jats:sec> <jats:title>Conclusion</jats:title> <jats:p><jats:italic>O. lupi</jats:italic> parasitosis can apparently remain cryptic in dogs for several years before any clinical signs manifest. Moreover, the progression of infection can be highly aggressive and recalcitrant to both surgical intervention and anthelminthic treatment. Increasingly, former stray dogs of unknown infection status are entering the UK, raising both veterinary and public health concerns.</jats:p> </jats:sec>

Item Type: Article
Uncontrolled Keywords: Onchocerca lupi, Importation, Public health, Humans, Dogs, One health
Divisions: Faculty of Health and Life Sciences
Faculty of Health and Life Sciences > Institute of Infection, Veterinary and Ecological Sciences
Depositing User: Symplectic Admin
Date Deposited: 22 Feb 2022 08:30
Last Modified: 18 Jan 2023 21:11
DOI: 10.1186/s12917-022-03169-9
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3149374