The faecal metabolome and mycobiome in Parkinson's disease

De Pablo-Fernandez, Eduardo, Gebeyehu, Gerum Gashaw, Flain, Luke, Slater, Rachael ORCID: 0000-0001-9765-6978, Frau, Alessandra ORCID: 0000-0002-6885-1042, Ijaz, Umer Zeeshan, Warner, Thomas and Probert, Chris ORCID: 0000-0003-0477-6714 (2022) The faecal metabolome and mycobiome in Parkinson's disease Parkinsonism & Related Disorders, 95. pp. 65-69. ISSN 1353-8020, 1873-5126

	Text PD mycobiome_R1_Final_clean.docx - Author Accepted Manuscript Download (88kB)
	Text TABLE 1.docx - Author Accepted Manuscript Download (38kB)
	Text Supplementary material_R1_Final.pdf - Author Accepted Manuscript Download (654kB) | Preview

Abstract

Background: Gut fungal composition and its metabolites have not been assessed simultaneously in Parkinson's disease (PD) despite their potential pathogenic contribution. Objective: To evaluate the faecal metabolome and mycobiome in PD by assessing volatile organic compounds (VOCs) and fungal rRNA. Methods: Faecal VOCs from 35 PD patients and two control groups (n = 35; n = 15) were assessed using gas chromatography and mass spectrometry. DNA was extracted from 44 samples: 18S rRNA gene amplicons were prepared and sequenced. Metabolomics, mycobiome and integrated analyses were performed. Results: Several VOCs were more abundant and short chain fatty acids were less abundant in PD. Hanseniaspora, Kazachstania, uncultured Tremellaceae and Penicillium genera were more abundant, and Saccharomyces less abundant in PD (FDR<0.0007). Torulaspora was associated with PD and two VOCs. Conclusion: PD patients had a distinct metabolome and mycobiome suggesting that fungal dysbiosis may contribute to PD pathogenesis.

Item Type:	Article
Uncontrolled Keywords:	Parkinson 's disease, Metabolomics, Mycobiome, Fungal dysbiosis, Volatile organic compounds
Divisions:	Faculty of Health & Life Sciences Faculty of Health & Life Sciences > Inst. Systems, Molec & Integrative Biology > Inst. Systems, Molec & Integrative Biology
Depositing User:	Symplectic Admin
Date Deposited:	15 Mar 2022 16:29
Last Modified:	01 Mar 2026 00:19
DOI:	10.1016/j.parkreldis.2022.01.005
Related Websites:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3149422
Disclaimer:	The University of Liverpool is not responsible for content contained on other websites from links within repository metadata. Please contact us if you notice anything that appears incorrect or inappropriate.