Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses.

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Dejnirattisai, Wanwisa, Huo, Jiandong, Zhou, Daming, Zahradník, Jiří, Supasa, Piyada, Liu, Chang, Duyvesteyn, Helen ME, Ginn, Helen M, Mentzer, Alexander J, Tuekprakhon, Aekkachai et al (show 63 more authors) , Nutalai, Rungtiwa, Wang, Beibei, Dijokaite, Aiste, Khan, Suman, Avinoam, Ori, Bahar, Mohammad, Skelly, Donal, Adele, Sandra, Johnson, Sile Ann, Amini, Ali, Ritter, Thomas, Mason, Chris, Dold, Christina, Pan, Daniel, Assadi, Sara, Bellass, Adam, Omo-Dare, Nikki, Koeckerling, David, Flaxman, Amy, Jenkin, Daniel, Aley, Parvinder K, Voysey, Merryn, Clemens, Sue Ann Costa, Naveca, Felipe Gomes, Nascimento, Valdinete, Nascimento, Fernanda, Fernandes da Costa, Cristiano, Resende, Paola Cristina, Pauvolid-Correa, Alex, Siqueira, Marilda M, Baillie, Vicky, Serafin, Natali, Ditse, Zanele, Da Silva, Kelly, Madhi, Shabir, Nunes, Marta C, Malik, Tariq, Openshaw, Peter Jm, Baillie, J Kenneth, Semple, Malcolm G ORCID: 0000-0001-9700-0418, Townsend, Alain R, Huang, Kuan-Ying A, Tan, Tiong Kit, Carroll, Miles W, Klenerman, Paul, Barnes, Eleanor, Dunachie, Susanna J, Constantinides, Bede, Webster, Hermione, Crook, Derrick, Pollard, Andrew J, Lambe, Teresa, OPTIC consortium, ISARIC4C consortium, Paterson, Neil G, Williams, Mark A, Hall, David R, Fry, Elizabeth E, Mongkolsapaya, Juthathip, Ren, Jingshan, Schreiber, Gideon, Stuart, David I and Screaton, Gavin R (2021) Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses. bioRxiv, 3 (01-03). 2021.12.03.471045-. ISSN 2692-8205, 2692-8205

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Abstract

On the 24 th November 2021 the sequence of a new SARS CoV-2 viral isolate spreading rapidly in Southern Africa was announced, containing far more mutations in Spike (S) than previously reported variants. Neutralization titres of Omicron by sera from vaccinees and convalescent subjects infected with early pandemic as well as Alpha, Beta, Gamma, Delta are substantially reduced or fail to neutralize. Titres against Omicron are boosted by third vaccine doses and are high in cases both vaccinated and infected by Delta. Mutations in Omicron knock out or substantially reduce neutralization by most of a large panel of potent monoclonal antibodies and antibodies under commercial development. Omicron S has structural changes from earlier viruses, combining mutations conferring tight binding to ACE2 to unleash evolution driven by immune escape, leading to a large number of mutations in the ACE2 binding site which rebalance receptor affinity to that of early pandemic viruses.

Item Type:	Article
Uncontrolled Keywords:	3207 Medical Microbiology, 32 Biomedical and Clinical Sciences, 3204 Immunology, Vaccine Related, Coronaviruses, Infectious Diseases, Immunization, Prevention, Emerging Infectious Diseases, Biotechnology, Infection, 3 Good Health and Well Being
Divisions:	Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Infection, Veterinary and Ecological Sciences
Depositing User:	Symplectic Admin
Date Deposited:	28 Feb 2022 08:05
Last Modified:	06 Dec 2024 20:06
DOI:	10.1101/2021.12.03.471045
Open Access URL:	http://doi.org/10.1101/2021.12.03.471045
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3149805