Acute kidney injury manifesting as renal tubular acidosis with proximal and distal renal tubular dysfunction in a dog with acute pancreatitis

Barton, James C ORCID: 0000-0002-6636-2085, Noble, Peter-John Mantyla ORCID: 0000-0002-2275-2014 and O'Connell, Erin M ORCID: 0000-0003-0400-9291 (2022) Acute kidney injury manifesting as renal tubular acidosis with proximal and distal renal tubular dysfunction in a dog with acute pancreatitis JOURNAL OF VETERINARY EMERGENCY AND CRITICAL CARE, 32 (4). pp. 524-531. ISSN 1479-3261, 1476-4431

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Abstract

Objective: To describe the clinical presentation and management of a critically ill dog with profound renal tubular acidosis (RTA) with proximal and distal renal tubular dysfunction. Case Summary: A 3-year-old neutered female Border Terrier was presented with frequent regurgitation resulting from acute pancreatitis with severe ileus. Venous acid–base analysis and complete urinalysis confirmed the presence of normal anion gap metabolic acidosis with inappropriately alkaline urine (pH 8), consistent with distal RTA. Urinalysis, urine amino acids, and urinary fractional excretion of electrolytes revealed glycosuria (with normoglycemia), aminoaciduria, and increased fractional excretion of sodium, calcium, and phosphate consistent with generalized proximal renal tubulopathy or Fanconi syndrome. The dog responded well to supportive care and alkaline therapy and made a complete recovery. New or Unique Information Provided: To the authors’ knowledge, this is the first description of RTA with proximal and distal renal tubular dysfunction in the veterinary literature. Furthermore, the authors hypothesize that the transient RTA was a manifestation of acute kidney injury secondary to acute pancreatitis, the first report of this in the literature.

Item Type:	Article
Uncontrolled Keywords:	canine, glomerular filtration rate, kidney injury, metabolic acidosis, tubulopathy
Divisions:	Faculty of Health & Life Sciences Faculty of Health & Life Sciences > Inst. Infection, Vet & Ecological Sciences
Depositing User:	Symplectic Admin
Date Deposited:	08 Mar 2022 12:09
Last Modified:	16 Jun 2026 11:06
DOI:	10.1111/vec.13186
Open Access URL:	https://doi.org/10.1111/vec.13186
Related Websites:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3150359
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