Micromechanical and Ultrastructural Properties of Abdominal Aortic Aneurysms

Hossack, Martin, Fisher, Robert, Torella, Francesco ORCID: 0000-0003-0529-7387, Madine, Jillian ORCID: 0000-0001-9963-5871, Field, Mark and Akhtar, Riaz ORCID: 0000-0002-7963-6874
(2022) Micromechanical and Ultrastructural Properties of Abdominal Aortic Aneurysms. Artery Research, 28 (1). pp. 15-30.

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<jats:title>Abstract</jats:title><jats:p>Abdominal aortic aneurysms are a common condition of uncertain pathogenesis that can rupture if left untreated. Current recommended thresholds for planned repair are empirical and based entirely on diameter. It has been observed that some aneurysms rupture before reaching the threshold for repair whilst other larger aneurysms do not rupture. It is likely that geometry is not the only factor influencing rupture risk. Biomechanical indices aiming to improve and personalise rupture risk prediction require, amongst other things, knowledge of the material properties of the tissue and realistic constitutive models. These depend on the composition and organisation of the vessel wall which has been shown to undergo drastic changes with aneurysmal degeneration, with loss of elastin, smooth muscle cells, and an accumulation of isotropically arranged collagen. Most aneurysms are lined with intraluminal thrombus, which has an uncertain effect on the underlying vessel wall, with some authors demonstrating a reduction in wall stress and others a reduction in wall strength. The majority of studies investigating biomechanical properties of ex vivo abdominal aortic aneurysm tissues have used low-resolution techniques, such as tensile testing, able to measure the global material properties at the macroscale. High-resolution engineering techniques such as nanoindentation and atomic force microscopy have been modified for use in soft biological tissues and applied to vascular tissues with promising results. These techniques have the potential to advance the understanding and improve the management of abdominal aortic aneurysmal disease.</jats:p>

Item Type: Article
Uncontrolled Keywords: Abdominal aortic aneurysm, Intraluminal thrombus, Ultrastructure, Micromechanics, Nanoindentation, Atomic force microscopy, Elastic modulus
Divisions: Faculty of Health and Life Sciences
Faculty of Health and Life Sciences > Institute of Systems, Molecular and Integrative Biology
Faculty of Science and Engineering > School of Engineering
Faculty of Science and Engineering > School of Physical Sciences
Depositing User: Symplectic Admin
Date Deposited: 08 Mar 2022 16:59
Last Modified: 18 Jan 2023 21:11
DOI: 10.1007/s44200-022-00011-3
Open Access URL: https://link.springer.com/content/pdf/10.1007/s442...
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3150362