Respiratory Syncytial Virus-related Death in Children With Down Syndrome

Löwensteyn, Yvette N, Phijffer, Emily WEM, Simons, Juliette VL, Scheltema, Nienke M, Mazur, Natalie I, Nair, Harish and Bont, Louis J
(2020) Respiratory Syncytial Virus-related Death in Children With Down Syndrome. Pediatric Infectious Disease Journal, 39 (8). pp. 665-670.

Access the full-text of this item by clicking on the Open Access link.


<jats:sec> <jats:title>Background:</jats:title> <jats:p>Respiratory syncytial virus (RSV) is a major cause of mortality in children younger than 5 years worldwide. Systematic reviews have shown that Down syndrome (DS) is an independent risk factor for severe RSV infection. We aimed to describe demographic and clinical characteristics of children with DS who died with RSV infection.</jats:p> </jats:sec> <jats:sec> <jats:title>Methods:</jats:title> <jats:p>We performed a retrospective case series in which data were shared by individual researchers, research networks and physicians worldwide as part of the RSV Global Online Database study. We included children with DS who died when younger than 5 years of age with laboratory-confirmed RSV infection.</jats:p> </jats:sec> <jats:sec> <jats:title>Results:</jats:title> <jats:p>We included 53 children with DS and RSV-related mortality from 20 countries in 5 continents. Five (9.4%) children were from low-income or lower-middle-income countries. Median age at time of death was 6.0 months [interquartile range (IQR): 3.00–12.0]. Thirteen (24.5%) children were born term and had no other risk factors for severe RSV disease. In total, 36 (67.9%) children had congenital heart disease, 8 (15.1%) had chronic lung disease and 1 (1.9%) had congenital immunodeficiency. Duration of hospitalization was significantly longer for children with DS compared with children without DS [median length of stay, 13 days (IQR: 6.8–21.0) vs. 8 days (IQR: 3.0–18.5), <jats:italic toggle="yes">P</jats:italic>=0.005].</jats:p> </jats:sec> <jats:sec> <jats:title>Conclusions:</jats:title> <jats:p>One-fourth of children with DS and RSV-confirmed death did not have risk factors for severe RSV disease, indicating that DS is an important risk factor for RSV-related mortality. Age distribution at time of death demonstrates that maternal vaccination would not be sufficient to protect children with DS against RSV-related mortality.</jats:p> </jats:sec>

Item Type: Article
Divisions: Faculty of Health and Life Sciences
Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences
Depositing User: Symplectic Admin
Date Deposited: 10 Mar 2022 10:01
Last Modified: 21 Sep 2023 10:01
DOI: 10.1097/inf.0000000000002666
Open Access URL:
Related URLs: