A blood atlas of COVID-19 defines hallmarks of disease severity and specificity


Ahern, David J, Ai, Zhichao, Ainsworth, Mark, Allan, Chris, Allcock, Alice, Angus, Brian, Ansari, M Azim, Arancibia-Carcamo, Carolina V, Aschenbrenner, Dominik, Attar, Moustafa et al (show 195 more authors) (2022) A blood atlas of COVID-19 defines hallmarks of disease severity and specificity. CELL, 185 (5). 916-+.

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Abstract

Treatment of severe COVID-19 is currently limited by clinical heterogeneity and incomplete description of specific immune biomarkers. We present here a comprehensive multi-omic blood atlas for patients with varying COVID-19 severity in an integrated comparison with influenza and sepsis patients versus healthy volunteers. We identify immune signatures and correlates of host response. Hallmarks of disease severity involved cells, their inflammatory mediators and networks, including progenitor cells and specific myeloid and lymphocyte subsets, features of the immune repertoire, acute phase response, metabolism, and coagulation. Persisting immune activation involving AP-1/p38MAPK was a specific feature of COVID-19. The plasma proteome enabled sub-phenotyping into patient clusters, predictive of severity and outcome. Systems-based integrative analyses including tensor and matrix decomposition of all modalities revealed feature groupings linked with severity and specificity compared to influenza and sepsis. Our approach and blood atlas will support future drug development, clinical trial design, and personalized medicine approaches for COVID-19.

Item Type: Article
Uncontrolled Keywords: COvid-19 Multi-omics Blood ATlas (COMBAT) Consortium. Electronic address: julian.knight@well.ox.ac.uk, COvid-19 Multi-omics Blood ATlas (COMBAT) Consortium, Lymphocytes, Monocytes, Humans, Sepsis, Mitogen-Activated Protein Kinase 14, Blood Proteins, Cell Cycle Proteins, Proteome, Transcription Factor AP-1, Severity of Illness Index, Principal Component Analysis, Adult, Middle Aged, Female, Male, Influenza, Human, Biomarkers, Machine Learning, COVID-19, SARS-CoV-2
Divisions: Faculty of Health and Life Sciences
Faculty of Health and Life Sciences > Institute of Infection, Veterinary and Ecological Sciences
Depositing User: Symplectic Admin
Date Deposited: 11 Mar 2022 08:12
Last Modified: 18 Jan 2023 21:11
DOI: 10.1016/j.cell.2022.01.012
Open Access URL: https://www.cell.com/cell/pdf/S0092-8674(22)00070-...
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3150543
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