A PAPER-BASED MICROFLUIDIC ANALYTICAL DEVICE WITH A HIGHLY INTEGRATED ON-CHIP VALVE FOR AUTONOMOUS ELISA

Cai, Tianyu, Duan, Sixuan, Fu, Hao, Zhu, Jia, Lim, Eng Gee, Huang, Kaizhu, Hoettges, Kai ORCID: 0000-0002-0415-1688, Liu, Xinyu, Song, Pengfei and IEEE, (2022) A PAPER-BASED MICROFLUIDIC ANALYTICAL DEVICE WITH A HIGHLY INTEGRATED ON-CHIP VALVE FOR AUTONOMOUS ELISA. In: 2022 IEEE 35th International Conference on Micro Electro Mechanical Systems Conference (MEMS), 2022-1-9 - 2022-1-13.

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Official URL: http://dx.doi.org/10.1109/mems51670.2022.9699652

Abstract

This paper reports a microfluidic paper-based analytical device (PAD), featuring a novel, highly integrated on-chip rotary valve, for autonomous enzyme-linked immunosorbent assay (ELISA). Unlike existing valving methods on PADs, this rotary valve allows regulation of multiple flows with a single valve, leading to ease of assembly and small footprint with a high integration level. The micromotor-controlled valve is also programmable and highly reliable, and has a fast response (76 ± 0.6ms, n=20, 500 times faster than previous smart material-enabled valves on PADs). Using this design, we performed autonomous ELISA, demonstrating a limit of detection (LOD) of 20 pM for rabbit IgG antibody detection with 100% valving reliability.

Item Type:	Conference or Workshop Item (Unspecified)
Uncontrolled Keywords:	autonomous ELISA, in-vitro diagnostics, Microfluidic paper-based analytical device, on-chip valve
Divisions:	Faculty of Science and Engineering > School of Electrical Engineering, Electronics and Computer Science
Depositing User:	Symplectic Admin
Date Deposited:	05 Apr 2022 09:26
Last Modified:	18 Jan 2023 21:05
DOI:	10.1109/mems51670.2022.9699652
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3152143