Pharmacogenomics of Drug Hypersensitivity Technology and Translation

Kuruvilla, Rebecca, Scott, Kathryn and Pirmohamed, Sir Munir (2022) Pharmacogenomics of Drug Hypersensitivity Technology and Translation. IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA, 42 (2). pp. 335-355.

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Abstract

Hypersensitivity reactions are caused by many structurally unrelated drugs used for many different diseases. These reactions vary in severity and can be fatal. Only a minority of patients are affected by drug hypersensitivity reactions. Predisposition seems to be mediated by genetic factors, particularly within the HLA system. Apart from HLA-B∗57:01 testing, which is routine to prevent abacavir hypersensitivity, uptake of HLA testing into clinical practice has been slow and challenging. As genomic medicine becomes mainstream, it will be important for genetic testing in this area to move from the current reactive strategy to a more pre-emptive approach.

Item Type:	Article
Uncontrolled Keywords:	Drug hypersensitivity, HLA, Pharmacogenetics, Implementation
Divisions:	Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Systems, Molecular and Integrative Biology
Depositing User:	Symplectic Admin
Date Deposited:	13 Apr 2022 13:56
Last Modified:	22 Apr 2023 01:30
DOI:	10.1016/j.iac.2022.01.006
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3152880