Longitudinal analysis of urinary proteins in lupus nephritis – A pilot study

Carlsson, Emil, Quist, Alexandra, Davies, Jennifer C, Midgley, Angela, Smith, Eve MD, Bruce, Ian N, Beresford, Michael W ORCID: 0000-0002-5400-9911 and Hedrich, Christian M ORCID: 0000-0002-1295-6179 (2022) Longitudinal analysis of urinary proteins in lupus nephritis – A pilot study. Clinical Immunology, 236. p. 108948.

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Official URL: http://dx.doi.org/10.1016/j.clim.2022.108948

Abstract

Approximately 30% of adult-onset systemic lupus erythematosus (SLE) patients develop lupus nephritis (LN). The gold standard for LN detection involves renal biopsies, invasive procedures not suitable for routine disease monitoring. A urinary biomarker panel comprised of lipocalin-like prostaglandin D synthase (LPGDS), transferrin, alpha-1-acid glycoprotein (AGP-1), ceruloplasmin, monocyte chemoattractant protein 1 (MCP-1) and soluble vascular cell adhesion molecule-1 (sVCAM-1) has shown promise to predict LN and response to rituximab at baseline. Whether these proteins predict LN during longitudinal sampling, however, remained unknown. Here, we quantified aforementioned urinary proteins at baseline (N = 25), six and twelve months (N = 17 each) after rituximab treatment. Urine MCP-1 (at six and twelve months) and AGP-1 (at twelve months) levels varied between patients with active vs mildly active/inactive LN. Findings support the use of urinary proteins to detect active LN in ongoing disease monitoring in adult-onset SLE patients, but need to be validated in larger cohorts.

Item Type:	Article
Uncontrolled Keywords:	Systemic lupus erythematosus, Lupus, Nephritis, Renal, Urine, Protein, Biomarker, Inflammation, BILAG
Divisions:	Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences
Depositing User:	Symplectic Admin
Date Deposited:	28 Apr 2022 07:27
Last Modified:	02 Feb 2023 02:30
DOI:	10.1016/j.clim.2022.108948
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3153978