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Bastard, Paul, Gervais, Adrian
ORCID: 0000-0002-1083-5787, Le Voyer, Tom, Rosain, Jérémie, Philippot, Quentin, Manry, Jérémy, Michailidis, Eleftherios
ORCID: 0000-0002-9907-4346, Hoffmann, Hans-Heinrich, Eto, Shohei, Garcia-Prat, Marina
ORCID: 0000-0001-5387-1908 et al (show 191 more authors) , Bizien, Lucy, Parra-Martínez, Alba, Yang, Rui, Haljasmägi, Liis, Migaud, Mélanie, Särekannu, Karita, Maslovskaja, Julia, de Prost, Nicolas, Tandjaoui-Lambiotte, Yacine, Luyt, Charles-Edouard, Amador-Borrero, Blanca, Gaudet, Alexandre, Poissy, Julien, Morel, Pascal
ORCID: 0000-0002-8916-7717, Richard, Pascale, Cognasse, Fabrice, Troya, Jesus, Trouillet-Assant, Sophie, Belot, Alexandre
ORCID: 0000-0003-4902-5332, Saker, Kahina, Garçon, Pierre, Rivière, Jacques G, Lagier, Jean-Christophe
ORCID: 0000-0003-0771-8245, Gentile, Stéphanie, Rosen, Lindsey B, Shaw, Elana
ORCID: 0000-0001-9265-8026, Morio, Tomohiro, Tanaka, Junko, Dalmau, David, Tharaux, Pierre-Louis
ORCID: 0000-0002-6062-5905, Sene, Damien, Stepanian, Alain, Megarbane, Bruno
ORCID: 0000-0002-2522-2764, Triantafyllia, Vasiliki, Fekkar, Arnaud, Heath, James R, Franco, José Luis, Anaya, Juan-Manuel, Solé-Violán, Jordi, Imberti, Luisa
ORCID: 0000-0002-2075-8391, Biondi, Andrea
ORCID: 0000-0002-6757-6173, Bonfanti, Paolo
ORCID: 0000-0001-7289-8823, Castagnoli, Riccardo
ORCID: 0000-0003-0029-9383, Delmonte, Ottavia M, Zhang, Yu, Snow, Andrew L, Holland, Steven M, Biggs, Catherine, Moncada-Vélez, Marcela, Arias, Andrés Augusto, Lorenzo, Lazaro, Boucherit, Soraya, Coulibaly, Boubacar, Anglicheau, Dany, Planas, Anna M, Haerynck, Filomeen, Duvlis, Sotirija, Nussbaum, Robert L, Ozcelik, Tayfun, Keles, Sevgi, Bousfiha, Ahmed A, El Bakkouri, Jalila, Ramirez-Santana, Carolina, Paul, Stéphane, Pan-Hammarström, Qiang, Hammarström, Lennart, Dupont, Annabelle, Kurolap, Alina
ORCID: 0000-0002-7005-3621, Metz, Christine N, Aiuti, Alessandro, Casari, Giorgio, Lampasona, Vito, Ciceri, Fabio, Barreiros, Lucila A, Dominguez-Garrido, Elena, Vidigal, Mateus, Zatz, Mayana, van de Beek, Diederik, Sahanic, Sabina, Tancevski, Ivan, Stepanovskyy, Yurii, Boyarchuk, Oksana, Nukui, Yoko, Tsumura, Miyuki, Vidaur, Loreto, Tangye, Stuart G, Burrel, Sonia, Duffy, Darragh, Quintana-Murci, Lluis, Klocperk, Adam, Kann, Nelli Y, Shcherbina, Anna, Lau, Yu-Lung, Leung, Daniel, Coulongeat, Matthieu, Marlet, Julien, Koning, Rutger, Reyes, Luis Felipe, Chauvineau-Grenier, Angélique, Venet, Fabienne, Monneret, Guillaume, Nussenzweig, Michel C, Arrestier, Romain, Boudhabhay, Idris, Baris-Feldman, Hagit, Hagin, David, Wauters, Joost, Meyts, Isabelle, Dyer, Adam H
ORCID: 0000-0003-1356-510X, Kennelly, Sean P, Bourke, Nollaig M, Halwani, Rabih, Sharif-Askari, Narjes Saheb, Dorgham, Karim, Sallette, Jérome, Sedkaoui, Souad Mehlal, AlKhater, Suzan, Rigo-Bonnin, Raúl, Morandeira, Francisco, Roussel, Lucie, Vinh, Donald C, Ostrowski, Sisse Rye, Condino-Neto, Antonio, Prando, Carolina, Bonradenko, Anastasiia, Spaan, András N, Gilardin, Laurent, Fellay, Jacques, Lyonnet, Stanislas, Bilguvar, Kaya, Lifton, Richard P, Mane, Shrikant, HGID Lab, , COVID Clinicians, , COVID-STORM Clinicians, , NIAID Immune Response to COVID Group, , NH-COVAIR Study Group, , Danish CHGE, , Danish Blood Donor Study, , St. James's Hospital, , SARS CoV2 Interest group, , French COVID Cohort Study Group, , Imagine COVID-Group, , Milieu Intérieur Consortium, , CoV-Contact Cohort, , Amsterdam UMC Covid-19, , Biobank Investigators, , COVID Human Genetic Effort, , CONSTANCES cohort, , 3C-Dijon Study, , Cerba Health-Care, , Etablissement du Sang study group, , Anderson, Mark S, Boisson, Bertrand
ORCID: 0000-0001-5240-3555, Béziat, Vivien
ORCID: 0000-0002-4020-824X, Zhang, Shen-Ying, Vandreakos, Evangelos, Hermine, Olivier, Pujol, Aurora, Peterson, Pärt, Mogensen, Trine H, Rowen, Lee, Mond, James, Debette, Stéphanie, de Lamballerie, Xavier, Duval, Xavier, Mentré, France, Zins, Marie, Soler-Palacin, Pere, Colobran, Roger, Gorochov, Guy
ORCID: 0000-0003-2097-9677, Solanich, Xavier, Susen, Sophie, Martinez-Picado, Javier, Raoult, Didier
ORCID: 0000-0002-0633-5974, Vasse, Marc, Gregersen, Peter K, Piemonti, Lorenzo, Rodríguez-Gallego, Carlos, Notarangelo, Luigi D, Su, Helen C, Kisand, Kai, Okada, Satoshi, Puel, Anne
ORCID: 0000-0003-2603-0323, Jouanguy, Emmanuelle, Rice, Charles M, Tiberghien, Pierre
ORCID: 0000-0002-9310-8322, Zhang, Qian, Cobat, Aurélie, Abel, Laurent and Casanova, Jean-Laurent
(2021)
Autoantibodies neutralizing type I IFNs are present in <b>~</b>4% of uninfected individuals over 70 years old and account for <b>~</b>20% of COVID-19 deaths.
Science immunology, 6 (62).
eabl4340-.
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Abstract
Circulating autoantibodies (auto-Abs) neutralizing high concentrations (10 ng/mL, in plasma diluted 1 to 10) of IFN-α and/or -ω are found in about 10% of patients with critical COVID-19 pneumonia, but not in subjects with asymptomatic infections. We detect auto-Abs neutralizing 100-fold lower, more physiological, concentrations of IFN-α and/or -ω (100 pg/mL, in 1/10 dilutions of plasma) in 13.6% of 3,595 patients with critical COVID-19, including 21% of 374 patients > 80 years, and 6.5% of 522 patients with severe COVID-19. These antibodies are also detected in 18% of the 1,124 deceased patients (aged 20 days-99 years; mean: 70 years). Moreover, another 1.3% of patients with critical COVID-19 and 0.9% of the deceased patients have auto-Abs neutralizing high concentrations of IFN-β. We also show, in a sample of 34,159 uninfected subjects from the general population, that auto-Abs neutralizing high concentrations of IFN-α and/or -ω are present in 0.18% of individuals between 18 and 69 years, 1.1% between 70 and 79 years, and 3.4% >80 years. Moreover, the proportion of subjects carrying auto-Abs neutralizing lower concentrations is greater in a subsample of 10,778 uninfected individuals: 1% of individuals <70 years, 2.3% between 70 and 80 years, and 6.3% >80 years. By contrast, auto-Abs neutralizing IFN-β do not become more frequent with age. Auto-Abs neutralizing type I IFNs predate SARS-CoV-2 infection and sharply increase in prevalence after the age of 70 years. They account for about 20% of both critical COVID-19 cases in the over-80s, and total fatal COVID-19 cases.
Item Type: |
Article
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Uncontrolled Keywords: |
HGID Lab, COVID Clinicians, COVID-STORM Clinicians, NIAID Immune Response to COVID Group, NH-COVAIR Study Group, Danish CHGE, Danish Blood Donor Study, St. James's Hospital, SARS CoV2 Interest group, French COVID Cohort Study Group, Imagine COVID-Group, Milieu Intérieur Consortium, CoV-Contact Cohort, Amsterdam UMC Covid-19, Biobank Investigators, COVID Human Genetic Effort, CONSTANCES cohort, 3C-Dijon Study, Cerba Health-Care, Etablissement du Sang study group, Humans, Critical Illness, Immunoglobulin G, Interferon Type I, Interferon-alpha, Autoantibodies, Case-Control Studies, Adolescent, Adult, Aged, Aged, 80 and over, Middle Aged, Child, Child, Preschool, Infant, Infant, Newborn, Young Adult, Antibodies, Neutralizing, COVID-19 |
Divisions: |
Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Infection, Veterinary and Ecological Sciences |
Depositing User: |
Symplectic Admin
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Date Deposited: |
04 May 2022 09:50 |
Last Modified: |
18 Jan 2023 21:04 |
DOI: |
10.1126/sciimmunol.abl4340 |
Open Access URL: |
https://doi.org/10.1126/sciimmunol.abl4340 |
Related URLs: |
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URI: |
https://livrepository.liverpool.ac.uk/id/eprint/3154270 |