Steel, David HH, Geraghty, Brendan 
ORCID: 0000-0003-0561-6667, Kearns, Victoria ORCID: 0000-0003-1426-6048, Stanzel, Boris and Wong, David
(2023)
Subretinal Injection Under Perfluorocarbon Liquids to Avoid Foveal Dehiscence
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES, 43 (9).
pp. 1612-1615.
ISSN 0275-004X, 1539-2864
Abstract
summary:We describe a novel technique modification of subretinal injection to reduce the risk of foveal dehiscence during subretinal tissue plasminogen activator delivery for submacular haemorrhage, using a perfluorocarbon liquid filled vitreous cavity and an eccentric injection point, with a viscous fluid injector system controlled injection.Purpose:To describe a novel method of subretinal injection to reduce the risk of foveal dehiscence during subretinal tissue plasminogen activator delivery for submacular hemorrhage.Method:Description of technique with illustrative case description and details of four cases treated. The subretinal injection is delivered under a perfluorocarbon liquid bubble filling 80% of the vitreous cavity. An eccentric injection point is used and the tissue plasminogen activator injected under a pneumatically controlled viscous fluid injection system with a 38-g polyimide cannula and low injection pressure.Results:Four cases have been treated with controlled subretinal injection extending under the fovea without dehiscence, including one case with apparent preexisting foveal dehiscence and a preretinal clot.Conclusion:The technique allows the creation of a low more diffuse subretinal bleb compared with without perfluorocarbon liquid, minimizing hydraulic stress on the fovea during injection and could be applied to other subretinal injection scenarios where the fovea is at risk of hydraulic blowout. Further experience of the technique is needed to validate this initial report.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | age-related macular degeneration, displacement, foveal dehiscence, perfluorocarbon liquids, submacular hemorrhage, subretinal injection, tissue plasminogen activator |
| Divisions: | Faculty of Health & Life Sciences Faculty of Health & Life Sciences > Inst. Life Courses & Medical Sciences |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 05 May 2022 13:56 |
| Last Modified: | 16 Jun 2026 12:46 |
| DOI: | 10.1097/IAE.0000000000003104 |
| Open Access URL: | https://eprints.ncl.ac.uk/file_store/production/27... |
| Related Websites: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3154328 |
| Disclaimer: | The University of Liverpool is not responsible for content contained on other websites from links within repository metadata. Please contact us if you notice anything that appears incorrect or inappropriate. |
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