Estimated transmissibility and impact of SARS-CoV-2 lineage B.1.1.7 in England

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Davies, Nicholas G ORCID: 0000-0002-1740-1412, Abbott, Sam ORCID: 0000-0001-8057-8037, Barnard, Rosanna C ORCID: 0000-0001-7602-0401, Jarvis, Christopher I ORCID: 0000-0002-0812-2446, Kucharski, Adam J, Munday, James D ORCID: 0000-0002-6206-7134, Pearson, Carl AB ORCID: 0000-0003-0701-7860, Russell, Timothy W ORCID: 0000-0001-5610-6080, Tully, Damien C ORCID: 0000-0002-7620-9340, Washburne, Alex D ORCID: 0000-0003-4047-3411 et al (show 13 more authors) , Wenseleers, Tom ORCID: 0000-0002-1434-861X, Gimma, Amy, Waites, William ORCID: 0000-0002-7759-6805, Wong, Kerry LM ORCID: 0000-0002-4400-2257, van Zandvoort, Kevin ORCID: 0000-0002-7770-0537, Silverman, Justin D ORCID: 0000-0002-3063-2098, Diaz-Ordaz, Karla ORCID: 0000-0003-3155-1561, Keogh, Ruth ORCID: 0000-0001-6504-3253, Eggo, Rosalind M ORCID: 0000-0002-0362-6717, Funk, Sebastian ORCID: 0000-0002-2842-3406, Jit, Mark ORCID: 0000-0001-6658-8255, Atkins, Katherine E ORCID: 0000-0001-5250-0558 and Edmunds, W John ORCID: 0000-0002-9179-2917 (2021) Estimated transmissibility and impact of SARS-CoV-2 lineage B.1.1.7 in England. Science, 372 (6538).

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Abstract

<jats:title>UK variant transmission</jats:title> <jats:p> Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has the capacity to generate variants with major genomic changes. The UK variant B.1.1.7 (also known as VOC 202012/01) has many mutations that alter virus attachment and entry into human cells. Using a variety of statistical and dynamic modeling approaches, Davies <jats:italic>et al.</jats:italic> characterized the spread of the B.1.1.7 variant in the United Kingdom. The authors found that the variant is 43 to 90% more transmissible than the predecessor lineage but saw no clear evidence for a change in disease severity, although enhanced transmission will lead to higher incidence and more hospital admissions. Large resurgences of the virus are likely to occur after the easing of control measures, and it may be necessary to greatly accelerate vaccine roll-out to control the epidemic. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.abg3055">eabg3055</jats:related-article> </jats:p>

Item Type:	Article
Divisions:	Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Infection, Veterinary and Ecological Sciences
Depositing User:	Symplectic Admin
Date Deposited:	09 May 2022 08:39
Last Modified:	18 Jan 2023 21:03
DOI:	10.1126/science.abg3055
Open Access URL:	https://doi.org/10.1126/science.abg3055
Related URLs:	Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3154480