Real world treatment of juvenile-onset systemic lupus erythematosus: Data from the UK JSLE cohort study

Smith, Eve MD, Egbivwie, Naomi, Jorgensen, Andrea L ORCID: 0000-0002-6977-9337, Ciurtin, Coziana, Al-Abadi, Eslam, Armon, Kate, Bailey, Kathryn, Brennan, Mary, Gardner-Medwin, Janet, Haslam, Kirsty
et al (show 16 more authors) (2022) Real world treatment of juvenile-onset systemic lupus erythematosus: Data from the UK JSLE cohort study. CLINICAL IMMUNOLOGY, 239. 109028-.

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<h4>Background</h4>In the absence of clinical trials evidence, Juvenile-onset Systemic Lupus Erythematosus (JSLE) treatment plans vary.<h4>Aim</h4>To explore 'real world' treatment utilising longitudinal UK JSLE Cohort Study data.<h4>Methods</h4>Data collected between 07/2009-05/2020 was used to explore the choice/sequence of immunomodulating drugs from diagnosis. Multivariate logistic regression determined how organ-domain involvement (pBILAG-2004) impacted treatment choice.<h4>Result</h4>349 patients met inclusion criteria, median follow-up 4-years (IQR:2,6). Mycophenolate mofetil (MMF) was most commonly used for the majority of organ-domains, and significantly associated with renal involvement (OR:1.99, 95% CI:1.65-2.41, p<sub>c</sub> < 0.01). Analyses assessing the sequence of immunomodulators focused on 197/349 patients (meeting relevant inclusion/exclusion criteria). 10/197 (5%) solely recieved hydroxychloroquine/prednisolone, 62/197 (31%) received a single-immunomodulator, 69/197 (36%) received two, and 36/197 patients (28%) received ≥three immunomodulators. The most common first and second line immunomodulator was MMF. Rituximab was the most common third-line immunomodulator.<h4>Conclusions</h4>Most UK JSLE patients required ≥two immunomodulators, with MMF used most commonly.

Item Type: Article
Uncontrolled Keywords: SLE, Childhood, Juvenile-onset SLE, Treatment, Immunosuppression
Divisions: Faculty of Health and Life Sciences
Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences
Depositing User: Symplectic Admin
Date Deposited: 09 May 2022 09:02
Last Modified: 18 Jan 2023 21:03
DOI: 10.1016/j.clim.2022.109028
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