Pharmacokinetics of ss-d-N4-Hydroxycytidine, the Parent Nucleoside of Prodrug Molnupiravir, in Nonplasma Compartments of Patients With Severe Acute Respiratory Syndrome Coronavirus 2 Infection

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FitzGerald, Richard, Dickinson, Laura ORCID: 0000-0001-5557-9396, Else, Laura, Fletcher, Thomas, Hale, Colin, Amara, Alieu ORCID: 0000-0002-1137-2948, Walker, Lauren ORCID: 0000-0002-3827-4387, Penchala, Sujan Dilly, Lyon, Rebecca, Shaw, Victoria ORCID: 0000-0002-0429-0186 et al (show 9 more authors) , Greenhalf, William ORCID: 0000-0002-1865-3195, Bullock, Katie ORCID: 0000-0002-5758-0179, Lavelle-Langham, Lara, Reynolds, Helen ORCID: 0000-0001-7443-4520, Painter, Wendy, Holman, Wayne, Ewings, Sean, Griffiths, Gareth and Khoo, Saye ORCID: 0000-0002-2769-0967 (2022) Pharmacokinetics of ss-d-N4-Hydroxycytidine, the Parent Nucleoside of Prodrug Molnupiravir, in Nonplasma Compartments of Patients With Severe Acute Respiratory Syndrome Coronavirus 2 Infection CLINICAL INFECTIOUS DISEASES, 75 (1). E525-E528. ISSN 1058-4838, 1537-6591

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Abstract

ß-d-N4-hydroxycytidine (NHC), the parent nucleoside of molnupiravir, a COVID-19 antiviral, was quantified at SARS-CoV-2 transmission sites in 12 patients enrolled in AGILE Candidate-Specific Trial-2. Saliva, nasal, and tear NHC concentrations were 3%, 21%, and 22% that of plasma. Saliva and nasal NHC were significantly correlated with plasma (P<.0001). Clinical Trials Registration. NCT04746183.

Item Type:	Article
Uncontrolled Keywords:	COVID-19, molnupiravir, nonplasma, pharmacokinetics, SARS-CoV-2
Divisions:	Faculty of Health & Life Sciences Faculty of Health & Life Sciences > Inst. Systems, Molec & Integrative Biology > Inst. Systems, Molec & Integrative Biology
Depositing User:	Symplectic Admin
Date Deposited:	16 May 2022 09:52
Last Modified:	24 Jan 2026 03:39
DOI:	10.1093/cid/ciac199
Open Access URL:	https://academic.oup.com/cid/advance-article/doi/1...
Related Websites:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3154864
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