Monitoring the elimination of <i>gambiense</i> human African trypanosomiasis in the historical focus of Batié, South–West Burkina Faso

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Compaoré, Charlie Franck Alfred, Kaboré, Jacques, Ilboudo, Hamidou, Thomas, Lian Francesca, Falzon, Laura Cristina, Bamba, Mohamed, Sakande, Hassane, Koné, Minayégninrin, Kaba, Dramane, Bougouma, Clarisse et al (show 7 more authors) , Adama, Ilboudo, Amathe, Ouedraogo, Belem, Adrien Marie Gaston, Fèvre, Eric Maurice, Büscher, Philippe, Lejon, Veerle and Jamonneau, Vincent ORCID: 0000-0001-8427-0769 (2022) Monitoring the elimination of <i>gambiense</i> human African trypanosomiasis in the historical focus of Batié, South–West Burkina Faso. Parasite, 29. 25 - 25.

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Abstract

<jats:p>The World Health Organisation has targeted the elimination of human African trypanosomiasis (HAT) as zero transmission by 2030. Continued surveillance needs to be in place for early detection of re-emergent cases. In this context, the performance of diagnostic tests and testing algorithms for detection of the re-emergence of <jats:italic>Trypanosoma brucei gambiense</jats:italic> HAT remains to be assessed. We carried out a door-to-door active medical survey for HAT in the historical focus of Batié, South–West Burkina Faso. Screening was done using three rapid diagnostic tests (RDTs). Two laboratory tests (ELISA/<jats:italic>T. b. gambiense</jats:italic> and immune trypanolysis) and parasitological examination were performed on RDT positives only. In total, 5883 participants were screened, among which 842 (14%) tested positive in at least one RDT. Blood from 519 RDT positives was examined microscopically but no trypanosomes were observed. The HAT Sero-<jats:italic>K</jats:italic>-Set test showed the lowest specificity of 89%, while the specificities of SD Bioline HAT and rHAT Sero-Strip were 92% and 99%, respectively. The specificity of ELISA/<jats:italic>T. b. gambiense</jats:italic> and trypanolysis was 99% (98–99%) and 100% (99–100%), respectively. Our results suggest that <jats:italic>T. b. gambiense</jats:italic> is no longer circulating in the study area and that zero transmission has probably been attained. While a least cost analysis is still required, our study showed that RDT preselection followed by trypanolysis may be a useful strategy for post-elimination surveillance in Burkina Faso.</jats:p>

Item Type:	Article
Divisions:	Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Infection, Veterinary and Ecological Sciences
Depositing User:	Symplectic Admin
Date Deposited:	16 May 2022 13:47
Last Modified:	18 Jan 2023 21:02
DOI:	10.1051/parasite/2022024
Open Access URL:	https://doi.org/10.1051/parasite/2022024
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3154893

Available Versions of this Item

• Monitoring the elimination of <i>gambiense</i> human African trypanosomiasis in the historical focus of Batié, South–West Burkina Faso. (deposited 16 May 2022 13:47) [Currently Displayed]
  • Monitoring the elimination of gambiense human African trypanosomiasis in the historical focus of Batie, South-West Burkina Faso. (deposited 18 May 2022 13:51)