Procalcitonin Is Not a Reliable Biomarker of Bacterial Coinfection in People With Coronavirus Disease 2019 Undergoing Microbiological Investigation at the Time of Hospital Admission



Relph, Katharine A, Russell, Clark D, Fairfield, Cameron J, Turtle, Lance ORCID: 0000-0002-0778-1693, de Silva, Thushan I, Siggins, Matthew K, Drake, Thomas M, Thwaites, Ryan S, Abrams, Simon, Moore, Shona C ORCID: 0000-0001-8610-2806
et al (show 358 more authors) (2022) Procalcitonin Is Not a Reliable Biomarker of Bacterial Coinfection in People With Coronavirus Disease 2019 Undergoing Microbiological Investigation at the Time of Hospital Admission. Open Forum Infectious Diseases, 9 (5).

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Abstract

<jats:title>Abstract</jats:title> <jats:p>Admission procalcitonin measurements and microbiology results were available for 1040 hospitalized adults with coronavirus disease 2019 (from 48 902 included in the International Severe Acute Respiratory and Emerging Infections Consortium World Health Organization Clinical Characterisation Protocol UK study). Although procalcitonin was higher in bacterial coinfection, this was neither clinically significant (median [IQR], 0.33 [0.11–1.70] ng/mL vs 0.24 [0.10–0.90] ng/mL) nor diagnostically useful (area under the receiver operating characteristic curve, 0.56 [95% confidence interval, .51–.60]).</jats:p>

Item Type: Article
Divisions: Faculty of Health and Life Sciences
Faculty of Health and Life Sciences > Institute of Infection, Veterinary and Ecological Sciences
Depositing User: Symplectic Admin
Date Deposited: 17 May 2022 07:49
Last Modified: 06 Aug 2022 07:12
DOI: 10.1093/ofid/ofac179
Open Access URL: https://doi.org/10.1093/ofid/ofac179
URI: https://livrepository.liverpool.ac.uk/id/eprint/3154932